Results 41 to 50 of about 18,413,854 (345)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Mortalidad infantil y marginación en la península de Yucatán

Investigaciones Geográficas, 2004
Se presentan resultados de un estudio orientado a conocer la distribución territorial de la mortalidad infantil y su relación con algunos indicadores socioeconómicos en la península de Yucatán, en el período 1990-2000.
Rosa María Méndez González, Ana García de Fuentes, María Dolores Cervera Montejano   +2 more
doaj  

Construction of Good Rank-1 Lattice Rules Based on the Weighted Star Discrepancy [PDF]

, 2006
The ‘goodness’ of a set of quadrature points in [0, 1]d may be measured by the weighted star discrepancy. If the weights for the weighted star discrepancy are summable, then we show that for n prime there exist n-point rank-1 lattice rules whose weighted
Joe, Stephen
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Playing Dead: Implications of Mortuary Evidence for the Social Construction of Childhood in Roman Britain 

Theoretical Roman Archaeology Journal, 2001
None
Rebecca Gowland
doaj   +2 more sources

The development of mouthwashes without anti-gonococcal activity for controlled clinical trials: an in vitro study [version 2; peer review: 2 approved]

F1000Research, 2020
Background: The oropharynx plays a major role in the development and spread of antimicrobial resistant Neisseria gonorrhoeae among men who have sex with men.
Christophe Van Dijck, Vicky Cuylaerts, Piet Sollie, Anna Spychala, Irith De Baetselier, Jolein Laumen, Tania Crucitti, Chris Kenyon   +7 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evaluating ISO 9001:2000 Certified and Non-Certified Organizations in Brazilian Leather-Footwear Chain

Brazilian Journal of Operations & Production Management, 2010
This study analyzes the Management Practices and Results constructs from several ISO 9001:2000 certified and non-certified organizations in the Brazilian leather-footwear chain in order to identify possible differences in performance between those and to
Marcelo Hoss Almeida, Carla Schwengber Ten Caten, Mariliz Gutterres   +2 more
doaj  

‘Romanisation’ and the Body

Theoretical Roman Archaeology Journal, 2001
None
Gilly Carr
doaj   +2 more sources