Results 61 to 70 of about 5,575,143 (306)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Journal of Pediatric and Neonatal Individualized Medicine, 2017 Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017 58th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNI ORGANIZING ...
--- Various Authors
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
BMJ, 2017 In 2008, when the NHS turned 60, a BMJ series concluded, “The most thoughtful birthday present the NHS could receive would be an extended period of calm before the next round of reforms is unleashed” (doi:10.1136/bmj.a524). Sadly, this isn’t what happened.
openaire +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Resolución CDEyVE Nº 116/2017. Modifica Reglamento de Carrera Académica.
, 2017 Fil: Consejo de Docencia, Extensión y Vida Estudiantil (D). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CDEyVE Nº 116/2017. Sustituye el artículo 54º del Reglamento de Carrera Académica Resolución CDEyVE Nº 87/2017 y modifica el Art.
Consejo de Docencia, Extensión y Vida Estudiantil (D)
core
Diwali Festival Celebration, 2017
, 2017 Photos from the 2017 Diwali celebrations at Swinburne University of Technology.
Vivien Bong
core +1 more source
How the Big Ten West Was Won: Football Recruiting
Organizacijų Vadyba: Sisteminiai Tyrimai, 2017 The paper analyses the 2017 Big Ten West Division football cycle models recruiting. The top ten recruit scores [(Rivals.com * 100) + [100 (outside surrounding); 75 (surrounding)] + extra credit walk-ons (100; 75)] allow proper ranking: Iowa, Nebraska ...
Diehl Kevin A.
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source