ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
GOLD 2021 Strategy Report: Implications for Asthma–COPD Overlap
, 2021 Miguel Román-Rodríguez, Alan Kaplan
openalex +1 more source
Comment on “Surface wave transmission line theory for single and many wire systems” [J. Appl. Phys. 130, 194902 (2021)] [PDF]
, 2022 J. A. Brandão Faria
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Deconstructing a Discipline. A Review of Taking Back Philosophy: A Multicultural Manifesto by Bryan Van Norden (Columbia University Press, 2017) [PDF]
, 2019 A review of Taking Back Philosophy: A Multicultural Manifesto by Bryan Van Norden (Columbia University Press, 2017).Page numbers for this review were updated on 01/05 ...
Levine, Jill
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Impact of the cold surge event in January 2021 on the power system of China
, 2022 Chang-Yi Liu +10 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ANALISIS PENGARUH PRODUK DOMESTIK REGIONAL BRUTO, TINGKAT PENGANGGURAN TERBUKA DAN TINGKAT PENDIDIKAN TERHADAP KEMISKINAN DI PROVINSI JAWA TIMUR TAHUN 2017-2021 [PDF]
The purpose of this study is to explain GRDP, Unemployment Rate and Education Level jointly affect the Poverty Rate in East Java Province in 2017-2021 in East Java and explain the more dominant independent variables between GDP, unemployment rate, level ...
Prameswara, Ramadhani Cesar
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source