Results 91 to 100 of about 14,235,430 (340)

33rd volume and 4th issue of Current Research in Dental Sciences 2023

Current Research in Dental Sciences
In the 33rd volume and 4th issue of Current Research in Dental Sciences 2023, "Songür E, Aksoy M, Özçelik B, Tulga Öz F. Disinfection effect of gaseous ozone on candida albicans and enterococcus faecalis: A randomized clinical trial in infected primary ...
Erratum E.
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Antenatal care visits and associated factors in Senegal: a multilevel poisson regression analysis of the 2023 DHS survey

Frontiers in Global Women's Health
BackgroundMaternal health is crucial for women's well-being during pregnancy, childbirth, and postpartum. Antenatal care (ANC) is essential for monitoring health and preventing complications, yet only 35.5% of women in low- and middle-income regions ...
Habtu Kifle Negash, Habtu Kifle Negash, Ashebir Mamay Gebiru, Ashebir Mamay Gebiru, Mihret Getnet, Mihret Getnet, Mihret Melese, Berihun Agegn Mengistie, Desalegn Anmut Bitew, Tilahun Nega Godana, Yosef Belay Bizuneh, Amare Belete Getahun, Amare Belete Getahun, Mikias Mered Tilahun, Nebebe Demis Baykemagn, Worku Chekol Tassew   +15 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A Process for Producing Ice Coverage Marine Information Objects (MIOs) in IHO S-57 Format [PDF]

, 2006
While global warming may be opening up more Arctic waters in the summer, ice still infests key shipping lanes in the northern hemisphere during the winter months.
Agi, Benson, Alexander, Lee, Coleman, David F, Dias, George, El-Rabbany, Ahmed   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

2023 ESC Guidelines for the management of acute coronary syndromes.

European Heart Journal, 2023
R. Byrne, X. Rosselló, J. J. Coughlan, E. Barbato, C. Berry, A. Chieffo, M. Claeys, G. Dan, M. Dweck, M. Galbraith, M. Gilard, L. Hinterbuchner, E. Jankowska, P. Jüni, Takeshi Kimura, V. Kunadian, M. Leósdóttir, R. Lorusso, R. Pedretti, A. Rigopoulos, M. Rubini Giménez, H. Thiele, P. Vranckx, S. Wassmann, N. Wenger, B. Ibáñez, S. Halvorsen, Stefan James, M. Abdelhamid, V. Aboyans, N. Marsan, S. Antoniou, R. Asteggiano, Maria Bäck, D. Capodanno, R. Casado-Arroyo, S. Cassese, J. Čelutkienė, M. Čikeš, J. Collet, G. Ducrocq, V. Falk, L. Fauchier, T. Geisler, Diana A Gorog, L. Holmvang, T. Jaarsma, H. W. Jones, L. Køber, Konstantinos C. Koskinas, D. Kotecha, Konstantin A. Krychtiuk, U. Landmesser, G. Lazaros, B. Lewis, B. Lindahl, A. Linhart, M. Løchen, M. Mamas, J. Mcevoy, B. Mihaylova, Richard Mindham, C. Mueller, L. Neubeck, J. Niebauer, J. Nielsen, A. Niessner, V. Paradies, A. Pasquet, Steffen E Petersen, E. Prescott, A. Rakisheva, B. Rocca, Giuseppe M C Rosano, L. Sade, F. Schiele, J. Siller-Matula, C. Sticherling, R. Storey, M. Thielmann, C. Vrints, S. Windecker, R. Wiseth, Adam Witkowski, Mohammed El Amine Bouzid, H. Hayrapetyan, B. Metzler, P. Lancellotti, Mugdim Bajrić, K. Karamfiloff, A. Mitsis, P. Ostadal, Rikke Sørensen, Tamer Elwasify, T. Marandi, Essi Ryödi, Archil Chukhrukidze, J. Mehilli, P. Davlouros, D. Becker, I. Guðmundsdóttir, J. Crowley, Y. Abramowitz, C. Indolfi, Orazbek Sakhov, S. Elezi, M. Beishenkulov, A. Erglis, N. Moussallem, Hisham Benlamin, Olivija Dobilienė, P. Degrell, M. Balbi, A. Grosu, Zouhair Lakhal, Jurrien ten Berg, H. Pejkov, K. Angel, M. de Sousa Almeida, O. Chioncel, L. Bertelli, S. Stojkovic, M. Studencan, P. Radsel, J. Ferreiro, A. Ravn-Fischer, L. Räber, Mohammed Yassin Bani Marjeh, M. Hassine, A. Yıldırır, A. Parkhomenko, A. Banning, E. Arbelo, C. Baigent, M. Borger, S. Buccheri, Borja Ibáñez, X. Rosselló, I. Vaartjes, K. Zeppenfeld   +139 more
semanticscholar   +1 more source