Results 51 to 60 of about 4,869,221 (316)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Revisores 2024

Revista del Hospital Italiano de Buenos Aires
El siguiente listado incluye a los profesionales que realizaron la revisión de trabajos enviados a la Revista del Hospital Italiano de Buenos Aires durante el año 2024.
Revista del Hospita Italiano de Buenos Aires
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types

Discover Oncology
Growth differentiation factor-15 (GDF15) is a cytokine/growth factor that belongs to the Transforming growth factor-ß (TGF-ß) protein family. The expression of GDF15 is low in most human organs under normal conditions.
Akhila Balakrishna Rai, Jalaluddin Akbar Kandel Codi, Giridhara Prema Suchitha, Kadabagere Narayanaswamy Hemavathi, Shobha Dagamajalu, Chandran S. Abhinand, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad   +7 more
doaj   +1 more source

Agradecimentos aos colaboradores de 2024

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia
O Corpo Editorial da revista Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Visa em Debate) agradece a todos os colaboradores pela parceria e pelo trabalho competente na avaliação dos manuscritos submetidos durante o ano de 2024.
Editoria Científica
doaj   +1 more source

Influence of corrosion and creep on intergranular fatigue crack path in 2XXX aluminium alloys [PDF]

, 2010
In this paper, two examples of the influence of time-dependent processes on crack path in two 2XXX aluminium alloys are presented. The first example is concerned with corrosion–fatigue crack growth resistance of a 2024 T351 alloy cracked in the S–L ...
Odemer, Grégory, Hénaff, Gilbert, Menan, Frédéric   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A New Medical Evaluation for Gastric Cancer Patients to Increase the Success Rate of Immunotherapy: A 2024 Update

Pharmaceuticals
Researchers have performed numerous studies on immunotherapy because of the high death rate associated with gastric cancer (GC). GC immunotherapy research has made tremendous progress, and we wanted to provide an update on this topic.
Gabriel Samasca, Claudia Burz, Irena Pintea, Adriana Muntean, Diana Deleanu, Iulia Lupan, Vasile Bintintan   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Síntesis de la jurisprudencia casacional sobre empleo público más significativa del segundo período del año 2024

Documentación Administrativa
A lo largo de la presente sección presentamos una síntesis de la jurisprudencia casacional sobre empleo público más significativa durante el segundo período del año 2024.
José Ramón Chaves García, Juan José Rastrollo Suárez   +1 more
doaj   +1 more source