Results 141 to 150 of about 34,531 (209)

Germ cell and other tumors in individuals with differences in sex development

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel, Miguel Reyes‐Múgica   +1 more
wiley   +1 more source

Production of hydroxyectoine from biogas by an engineered strain of Methylomicrobium alcaliphilum using a novel Taylor‐flow bioreactor

Journal of Chemical Technology &Biotechnology, Volume 100, Issue 7, Page 1425-1433, July 2025.
Abstract BACKGROUND The production of compatible solutes, such as ectoine and hydroxyectoine, is of great interest due to their industrial and biotechnological applications. Methylomicrobium alcaliphilum was genetically engineered to replace a native gene with a heterologous one, aiming to enhance ectoine production.
Raquel Herrero‐Lobo, Nuria Fernández‐González, Eva Marcos, María Alejandra Martínez, Pedro García‐Encina, María del Rosario Rodero, Raúl Muñoz, Sergio Bordel   +7 more
wiley   +1 more source

ILC2 Diversity, Location, and Function in Pulmonary Disease

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT Type‐2 inflammation is driven by the production of canonical type‐2 cytokines IL‐4, IL‐5, and IL‐13. Type‐2 cytokines promote mucus production, innate immune cell recruitment, and smooth muscle contractility in mucosal tissues. These hallmarks of type‐2 inflammation are important contributors to the weep‐and‐sweep responses observed in the ...
Mukesh Verma, Uryan I. Can, R. Lee Reinhardt   +2 more
wiley   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein‐Losing Enteropathies: A Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background The effects of vitamin D supplementation are unknown in dogs with protein‐losing enteropathy (PLE). Objective To evaluate the safety, efficacy, and clinical benefit of orally administered cholecalciferol in dogs with PLE and decreased serum concentrations of 25OHD.
Sara A. Jablonski, Sarah B. Shropshire, Victoria E. Watson, Alison C. Manchester, Harry Cridge, Elizabeth M. Lennon, M. Katherine Tolbert   +6 more
wiley   +1 more source

Light Quantity Impacts Early Response to Cold and Cold Acclimation in Young Leaves of Arabidopsis

Plant, Cell &Environment, Volume 48, Issue 7, Page 5030-5052, July 2025.
ABSTRACT Plant reactions to stress vary with development stage and fitness. This study assessed the relationship between light and chilling stress in Arabidopsis acclimation. By analysing the transcriptome and proteome responses of expanding leaves subjected to varying light intensity and cold, 2251 and 2064 early response genes and proteins were ...
Markéta Luklová, Marieke Dubois, Michaela Kameniarová, Klára Plačková, Jan Novák, Romana Kopecká, Michal Karady, Jaroslav Pavlů, Jan Skalák, Sunita Jindal, Ljiljana Tubić, Zainab Quddoos, Ondřej Novák, Dirk Inzé, Martin Černý   +14 more
wiley   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, Volume 35, Issue 23, June 5, 2025.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Seon Yeong Chae, Min Jae Kim, Ki Jun Yu, Hwa Kyoung Shin, Suck Won Hong   +7 more
wiley   +1 more source

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

Advanced Science, Volume 12, Issue 22, June 12, 2025.
In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin, Sophie E. Davies, Martin Hewison, Kerry S. Jones, Javier T. Gonzalez, James A. Betts, Carl Jenkinson, Mark A. Lindsay, Sarah R. Meadows, Damon A. Parkington, Albert Koulman, Dylan Thompson   +11 more
wiley   +1 more source

Spatiotemporal distribution of neural crest cells in the common wall lizard Podarcis muralis

Developmental Dynamics, Volume 254, Issue 6, Page 551-567, June 2025.
Abstract Background Neural crest cells (NCCs) are migratory embryonic stem cells that give rise to a diverse set of cell types. Here we describe the dynamic distribution of NCCs in developing embryos of the common wall lizard Podarcis muralis inferred from 10 markers.
Robin Pranter, Nathalie Feiner
wiley   +1 more source

Optimal Selenium Fertilizer Affects the Formation of Foxtail Millet (Setaria italica L.) Quality by Regulating Flavonoid Metabolism and Amino Acid Metabolism

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
S2 treatment regulated the flavonoid and histidine metabolism pathways of Jingu 21, reduced the protein content, increased the fat and starch contents, and decreased the peak viscosity and breakdown value. S2 treatment regulated the Stilbenoid, diarylheptanoid, and gingerol pathway of Jingu 40, and S3 treatment activated the tyrosine metabolic pathway ...
Shu Wang, Jiao Mao, Yuanmeng Xu, Sichen Liu, Zhijun Qiao, Xiaoning Cao   +5 more
wiley   +1 more source