Results 151 to 160 of about 34,531 (209)

Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice

Glia, Volume 73, Issue 6, Page 1188-1202, June 2025.
Main Points Dopamine depletion reduces locomotion‐induced calcium activity in dorsal striatal astrocytes. Chemogenetic activation facilitates astrocyte locomotion responses and improves motor behavior in dopamine lesioned animals. ABSTRACT Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal inputs, which causes ...
Wesley R. Evans, Sindhuja S. Baskar, Angelica Vellore, Ana Raquel Castro E. Costa, Cynthia Jacob, Sanya Ravoori, Abimbola Arigbe, Rafiq Huda   +7 more
wiley   +1 more source

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application

MedComm, Volume 6, Issue 6, June 2025.
Before the cancer cells arrive to the lung through blood vessels, these cancer cells secreted specific factors for two main purposes: first, to recruit bone marrow‐derived cells; and second, to regulate the activation of target cells. Additionally, the unique structure of the lungs provides a comfortable environment. Consequently, the formation of lung
Chenghao Cao, Di Lu, Huigang Li, Shen Pan, Jianyong Zhuo, Zuyuan Lin, Chiyu He, Peiru Zhang, Songmin Ying, Xuyong Wei, Shusen Zheng, Zhe Yang, Xiao Xu   +12 more
wiley   +1 more source

Bioenergetics of protein transport into mitochondria [PDF]

, 1988
Döhren, H. von, Jaenicke, L., Kleinkauf, Horst, Neupert, Walter, Pfanner, Nikolaus   +4 more
core  

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

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Clinical outcomes in 21-hydroxylase deficiency

Current Opinion in Endocrinology, Diabetes & Obesity, 2021
Purpose of review The introduction of synthetic glucocorticoids 70 years ago made survival possible in classic 21-hydroxylase deficiency (21OHD). The currently used glucocorticoid therapy may lead to unphysiological dosing with negative consequencies on health in addition to the problems that may arise due to androgen over ...
Anna Nordenström, Svetlana Lajic, Henrik Falhammar   +2 more
openaire   +3 more sources

21‐Hydroxylase Deficiency

Annals of the New York Academy of Sciences, 1997
A deficiency of 21-hydroxylase in the adrenal cortex results in insufficient cortisol production. The salt-wasting form of21-hydroxylase deficiency is characterized by inadequate aldosterone production, as well. Because the hypothalamic-adr enal negative feedback system is broken, excess adrenal androgens are produced.
Ron S. Newfield, Maria I. New
openaire   +3 more sources

Nonclassic 21-Hydroxylase Deficiency in Croatia

Journal of Pediatric Endocrinology and Metabolism, 2004
This is the first report of nonclassic congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency in Croatia in which the patients have been evaluated clinically, hormonally, and by molecular genetic analysis. Genetic analysis was performed on 18 Croatian patients with nonclassic CAH due to 21-OH deficiency using allele-specific PCR.
Jasenka Ille, Ji-Qing Wei, Veselin Škrabić, Robert C. Wilson, Vesna Plavšić, Anita Spehar, Igor Francetić, Zunec R, Nevena Janjanin, Miroslav Dumić, Maria I. New   +10 more
openaire   +4 more sources

Epidemiology of 21-Hydroxylase Deficiency in Singapore

Journal of Pediatric Endocrinology and Metabolism, 2002
We report the incidence and epidemiology of 21-hydroxylase deficiency in Singapore, based on a retrospective study of all known patients diagnosed with classical 21-hydroxylase deficiency in the past 21 years. The database was obtained from the case registry and questionnaire methodology, with 100% coverage of all practising pediatricians in Singapore.
Loke, K.Y., Tan, I.T., Lee, W.R.W., Lee, Y.S.   +3 more
openaire   +2 more sources

Late-Onset 21-Hydroxylase Deficiency

Annals of Internal Medicine, 1982
Excerpt To the editor: Since our article on the diagnosis of late-onset 21-hydroxylase deficiency was published (1), we have been asked the best way to do the 30-minute adrenocorticotrophic hormone...
Gordon B. Cutler, Abraham K. Munabi, D. Lynn Loriaux, George P. Chrousos   +3 more
openaire   +3 more sources

Steroid 21-Hydroxylase Deficiency in Mice*

Endocrinology, 1988
The enzyme steroid 21-hydroxylase (21-OHase) plays a key role in adrenal steroidogenesis. Defects in this enzyme are responsible for one of the most common inborn errors of metabolism in humans. Duplicated genes for the enzyme are located in the class III region of the major histocompatibility complex (MHC), HLA.
Hideo Gotoh, Kazuo Moriwaki, Jun-ichi Hata, Toshihiko Shiroishi, Tomoko Sagai   +4 more
openaire   +3 more sources