Results 221 to 230 of about 75,903 (304)

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia. [PDF]

Front Endocrinol (Lausanne)
Aldalaan H, Alsagheir A, Alghamdi N, Alhuthil R, Almslam M, Al-Hamed MH.   +5 more
europepmc   +1 more source

The Keto Functions of Heme d1 Are Introduced by NirF and NirC

ChemBioChem, Volume 27, Issue 10, -Not available-.
During heme d1 biosynthesis, the proteins NirF and NirC together catalyze the formation of dihydro‐heme d1, thereby introducing the unique keto functions of heme d1. In this paper, the development of an in vitro enzyme activity assay for NirF/NirC is described, which demonstrates the function of the two proteins for the first time.
Pia Hebecker, Gunhild Layer
wiley   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Future Directions in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

J Clin Endocrinol Metab
Sarafoglou K, Auchus RJ.
europepmc   +1 more source

Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: A narrative review and pooled analysis of clinical outcomes and treatment delivery approaches

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Purpose Stereotactic arrhythmia radioablation (STAR) has emerged as a noninvasive salvage therapy for refractory ventricular tachycardia (VT), particularly in patients ineligible for catheter ablation (CA). This narrative review and pooled analysis evaluates STAR's efficacy, safety, and technical characteristics, integrating evidence from ...
Keyur D. Shah, Chih‐Wei Chang, Sibo Tian, Pretesh Patel, Richard Qiu, Shadab Momin, Justin Roper, Jun Zhou, Zhen Tian, Xiaofeng Yang   +9 more
wiley   +1 more source

Editorial: Rare forms of pediatric adrenal disorders: beyond congenital adrenal hyperplasia due to 21-hydroxylase deficiency. [PDF]

Front Endocrinol (Lausanne)
Ferrigno R, Salerno M, Savage MO.
europepmc   +1 more source

Clinical characteristics and treatment during preconception and perinatal period of infertile women with non-classical 21-hydroxylase deficiency. [PDF]

Reprod Health
Cui X, Li P.
europepmc   +1 more source

Life With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Challenges and Burdens.

J Clin Endocrinol Metab
Witchel SF, Miller T, McCann E, Gupta A.
europepmc   +1 more source

Congenital Adrenal Hyperplasia - A Comprehensive Review of Genetic Studies on 21-Hydroxylase Deficiency from India. [PDF]

Indian J Endocrinol Metab
Ravichandran L, Asha HS, Mathai S, Thomas N, Chapla A.   +4 more
europepmc   +1 more source