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Clinical outcomes in 21-hydroxylase deficiency

Current Opinion in Endocrinology, Diabetes & Obesity, 2021
Purpose of review The introduction of synthetic glucocorticoids 70 years ago made survival possible in classic 21-hydroxylase deficiency (21OHD). The currently used glucocorticoid therapy may lead to unphysiological dosing with negative consequencies on health in addition to the problems that may arise due to androgen over ...
Anna, Nordenström   +2 more
openaire   +2 more sources

21‐Hydroxylase Deficiency

Annals of the New York Academy of Sciences, 1997
A deficiency of 21-hydroxylase in the adrenal cortex results in insufficient cortisol production. The salt-wasting form of21-hydroxylase deficiency is characterized by inadequate aldosterone production, as well. Because the hypothalamic-adr enal negative feedback system is broken, excess adrenal androgens are produced.
R S, Newfield, M I, New
openaire   +2 more sources

Nonclassic 21-Hydroxylase Deficiency in Croatia

Journal of Pediatric Endocrinology and Metabolism, 2004
This is the first report of nonclassic congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency in Croatia in which the patients have been evaluated clinically, hormonally, and by molecular genetic analysis. Genetic analysis was performed on 18 Croatian patients with nonclassic CAH due to 21-OH deficiency using allele-specific PCR.
Dumić, Miroslav   +10 more
openaire   +4 more sources

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