Results 241 to 250 of about 75,592 (343)
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler +4 more
wiley +2 more sources
TNF/TNFR1 is a Key Regulator of Prolonged Fasting‐Induced Decrease in Adipose Tissue
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Fasting triggers an inflammatory response and increases sympathetic tone in white adipose tissue (WAT), promoting fat breakdown and tissue remodeling. Fasting sparks an inflammatory response that underpins the reduction in adipocyte size and WAT remodeling.
Amanda Carla Clemente de Oliveira +12 more
wiley +1 more source
A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao +9 more
wiley +1 more source
Editorial: Rare forms of pediatric adrenal disorders: beyond congenital adrenal hyperplasia due to 21-hydroxylase deficiency. [PDF]
Front Endocrinol (Lausanne)Ferrigno R, Salerno M, Savage MO.
europepmc +1 more source
Clinical characteristics and treatment during preconception and perinatal period of infertile women with non-classical 21-hydroxylase deficiency. [PDF]
Reprod HealthCui X, Li P.
europepmc +1 more source