Studies on the mode of action of excess of vitamin A. 2. A possible role of intracellular proteases in the degradation of cartilage matrix [PDF]
, 1961 J. A. Lucy, J. T. Dingle, Honor B. Fell
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma
Brazilian Journal of Otorhinolaryngology, 2021 Introduction: The role of matrix metalloproteinase-2 and 9 in the metastasis and development of hypopharyngeal carcinoma has not been clarified. Objectives: To observe the relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and ...
Zhe Song +5 more
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
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Effect of Different Ga Contents on the Acid and Alkaline Resistance of New SnInAg Lead-Free Solder Alloy [PDF]
Cailiao BaohuIn order to improve the corrosion resistance of Sn-11In-1.5Ag lead-free solder alloy solder, the corrosion behavior of Sn-11In-1.5Ag-xGa(x=0, 0.1, 0.3, 0.5, 0.7, mass fraction, %) solder alloy in a corrosive environment was studied by weight loss method ...
REN Pengkai, XU Dongxia, CAO Fulei, CHU Yadong, ZHANG Hongxia
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On the Ratio L12/L21 For n = 2 Eigenvalue Problems: An Empirical Constraint For The Calculation of Force Constants (Extended L Matrix Approximation) [PDF]
, 1972 Achim Müller, N. Mohan, U. Heidborn
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Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
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Exact conditions for preservation of the partial indices of a perturbed triangular 2 × 2 matrix function. [PDF]
Proc Math Phys Eng Sci, 2020 Adukov VM, Mishuris G, Rogosin SV.
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Notizen: Matrixisolierungs- und Isotopensubstitutionstechnik: Germaniumisotopenaufspaltung der v3(F2)-Schwingung von GeCl4 und Chlorisotopenaufspaltung von GeClnCl4-n / Matrix Isolation and Isotopic Substitution Technique: Germanium Isotopic Splitting Pattern of the v3(F2) Mode of GeCl4 and Chlorine Isotopic Splitting Pattern of GeClnCl4-n [PDF]
, 1975 F. Königer +2 more
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