Results 51 to 60 of about 4,042,033 (199)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: The role of matrix metalloproteinase-2 and 9 in the metastasis and development of hypopharyngeal carcinoma has not been clarified. Objectives: To observe the relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and ...
Zhe Song, Junfu Wang, Qinghong Su, Meng Luan, Xuemei Chen, Xiaoqun Xu   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Research Progress on the Interfacial Modification Strategies and Interfacial Heat Transfer Mechanisms in Diamond/Copper Composites [PDF]

Cailiao Baohu
With the rapid development of information technology and the increasing integration of electronic devices，the thermal management performance of electronic packaging materials faces higher requirements.Diamond/copper composites have attracted considerable
LIU Yufei, XU Bin, LIU Yue
doaj   +1 more source

The universal R-matrix for the Jordanian deformation of sl(2), and the contracted forms of so(4)

, 1995
We introduce a universal R matrix for the Jordanian deformation of $\U{ \sl(2)}$. Using $\Uh{\so(4)}=\Uh{\sl(2)} \oplus {\rm U}_{-h}(\sl(2))$, we obtain the universal R matrix for $\Uh{\so(4)}$.
Aghamohammadi, A., Khorrami, M., Shariati, A.   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental Study on Accurate Determination of Shale Porosity by Nuclear Magnetic Resonance

Chinese Journal of Magnetic Resonance
In recent years, the exploration and development of shale oil and gas have expanded significantly, accompanied by numerous challenges. Porosity is a fundamental parameter for shale reservoir evaluation and reserve estimation, providing essential data for
DU Qunjie
doaj   +1 more source

PT-Symmetric Representations of Fermionic Algebras

, 2011
A recent paper by Jones-Smith and Mathur extends PT-symmetric quantum mechanics from bosonic systems (systems for which $T^2=1$) to fermionic systems (systems for which $T^2=-1$).
A. Messiah, Carl M. Bender, J. D. Bjorken, S. P. Klevansky   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Synthesis of Cis-Cisoid or Cis-Transoid Poly(Phenyl-Acetylene)s Having One or Two Carbamate Groups as Oxygen Permeation Membrane Materials

Membranes, 2020
Three new phenylacetylene monomers having one or two carbamate groups were synthesized and polymerized by using (Rh(norbornadiene)Cl)2 as an initiator. The resulting polymers had very high average molecular weights (Mw) of 1.4–4.8 × 106, with different ...
Yu Zang, Yinghui Lun, Masahiro Teraguchi, Takashi Kaneko, Hongge Jia, Fengjuan Miao, Xunhai Zhang, Toshiki Aoki   +7 more
doaj   +1 more source