Results 81 to 90 of about 27,833,629 (262)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Le portugais à l’Université Rennes 2 : histoire de l’évolution d’une discipline

International audienceParler de la création ou la disparition de l'enseignement d'une langue étrangère au sein de l'université, de sa promotion, et des enjeux liés à son maintien, revient à aborder la politique linguistique.
Boganika, Luciane
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Les libertés fondamentales face aux nouveaux enjeux sécuritaires

, 2021
Entretien réalisé par Marie Lauricella, "Rchrch, le magazine de la recherche de l’Université Lumière Lyon 2", n°1 (janvier 2021), pp. 23-25, URL : https://www.univ-lyon2.fr/recherche/magazine/rchrch-numero1-janvier-2021Entretien réalisé par Marie ...
Magnon-Pujo, Cyril, Lauricella, Marie, Souvignet, Xavier   +2 more
core  

Generalized ℤ 2 × ℤ 2 in scaling neutrino Majorana mass matrix and baryogenesis via flavored leptogenesis

Journal of High Energy Physics, 2017
We investigate the consequences of a generalized ℤ 2 × ℤ 2 symmetry on a scaling neutrino Majorana mass matrix. It enables us to determine definite analytical relations between the mixing angles θ 12 and θ 13, maximal CP violation for the Dirac type and ...
Roopam Sinha, Rome Samanta, Ambar Ghosal
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Trigeminal Electrophysiology: a 2 × 2 matrix model for differential diagnosis between temporomandibular disorders and orofacial pain

BMC Musculoskeletal Disorders, 2010
Background Pain due to temporomandibular disorders (TMDs) often has the same clinical symptoms and signs as other types of orofacial pain (OP). The possible presence of serious neurological and/or systemic organic pathologies makes differential diagnosis
Chessa Giacomo, Frisardi Gianni, Sau Gianfranco, Frisardi Flavio   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997

, 1997
videoThis 3 minutes, 1 second video clip from Salt Lake City\u27s KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human ...
KUTV, Channel 2
core  

Study of Cyclooxygenase-2 (A-1195G) and Matrix Metalloproteinase-2 (C-1360T) Genes Single Nucleotide Polymorphisms in Association with Colorectal Carcinoma [PDF]

Ain Shams Medical Journal
Background: Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related death in the world, with around 900,000 deaths per year.COX-2 expression is associated with MMP-2 expression in numerous ...
Ghada Thabet, Samar Saad, Mohamed Mohamed, Nahla Fawzy, Nevine ElAbd   +4 more
doaj   +1 more source