Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
How large are departures from lithostatic pressure? Constraints from host-inclusion elasticity [PDF]
, 2015 Minerals trapped as inclusions within other host minerals will develop non-lithostatic pressures during both prograde and retrograde metamorphism because of the differences between the thermo-elastic properties of the host and inclusion phases.
Adams +39 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Ocular Proteomics with Emphasis on Two-Dimensional Gel Electrophoresis and Mass Spectrometry
Biological Procedures Online, 2010 The intention of this review is to provide an overview of current methodologies employed in the rapidly developing field of ocular proteomics with emphasis on sample preparation, two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass ...
Honoré Bent +4 more
doaj
Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis [PDF]
, 2011 <b>Background</b>: Serum electrophoretic profiles in cats are poorly characterized with respect to the protein components of the globulin fractions, and interpretation of the electrophoretograms has routinely been done in ignorance of the ...
Baker +36 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Root protein interatomic network obtained from citrus seedlings subjected to water deficit : S08O03 [PDF]
, 2012 Citrus Brazilian industry may be strongly affected by drought. Characterize rootstock behavior under different environmental conditions is crucial, since rootstocks may confer better adaption to environmental stresses.
Bonatto, Diego +7 more
core
Where should MMS look for electron diffusion regions?
, 2015 A great possible achievement for the MMS mission would be crossing electron diffusion regions (EDR). EDR are regions in proximity of reconnection sites where electrons decouple from field lines, breaking the frozen in condition.
Goldman, M. +3 more
core +1 more source
Speziesspezifische proteomische Aspekte der axonalen Regeneration retinaler Ganglienzellen am Beispiel der Ratte (Rattus norvegicus) und des Affen (Callithrix jacchus) [PDF]
, 2004 Die axonale Regeneration im Zentralen Nervensystem (ZNS) ist ein äußerst komplexer Vorgang, der unter natürlichen Bedingungen nicht stattfindet, gleichwohl jedoch prinzipiell möglich ist.
Imming, Peter (Prof. Dr.), Rose, Karin
core +1 more source