Synthesis of 2-halo-2H-azirines [PDF]
Tetrahedron, 2001 Abstract α-Oxophosphonium ylides react with N -chlorosuccinimide, N -bromosuccinimide and N -iodosuccinimide in the presence of azidotrimethylsilane giving the corresponding haloazidoalkenes which were completely converted to the 2-halo-2 H -azirines on heating in heptane.
Ana Lopes
exaly +5 more sources
Synthesis and Application of Bioactive N-Functionalized Aziridines. [PDF]
Angew Chem Int Ed EnglThis review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Tan H +4 more
europepmc +3 more sources
Reactivity of 2-halo-2H-azirines. Part 3: Dehalogenation of 2-halo-2H-azirine-2-carboxylates [PDF]
Tetrahedron, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Pinho e Melo, Teresa M. V. D. +2 more
openaire +4 more sources
2H-Azirines as electrophiles [PDF]
, 2011 2H-Azirines have shown an unusual potential to synthesise aziridines and other types of compounds. Many functionalized aziridines can be produced by addition of O-, S-,N-, C-nucleophiles and hydride to 2H-azirines. This review is designed to give an overview of the reactivity of 2H-azirines as electrophiles along the years and their usefulness in the ...
Alves, M. José, Costa, Flora Teixeira e
core +4 more sources
Late-Stage Functionalization of Peptides on the Solid Phase. [PDF]
Angew Chem Int Ed EnglPeptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Werner M, Pham TL, Thomas F.
europepmc +2 more sources
Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis [PDF]
Nature CommunicationsFor decades, progress in chiral transition metal catalysis has been closely linked to the design of tailor-made chiral ligands. Recently, an alternative to this conventional paradigm has emerged in which the overall chirality of the catalysts arises ...
Su-Yang Yao +7 more
doaj +2 more sources
Synthetic Strategies to Access Fluorinated Azoles. [PDF]
European J Org ChemThis review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
El-Gaber MKA +4 more
europepmc +2 more sources
Substituent Effects Govern the Efficiency of Isoxazole Photoisomerization to Carbonyl‑2H‑Azirines [PDF]
ACS Organic & Inorganic AuKyra E. Jackson +3 more
doaj +2 more sources
Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines [PDF]
Synlett, 2015 Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-substituted aziridines through a telescoped reaction sequence involving nitrile, trifluoromethyl, or ...
Baumann, Marcus, Baxendale, Ian R.
openaire +5 more sources
Selective Synthesis of 3‑(1H‑Tetrazol-5-yl)-indoles from 2H‑Azirines and Arynes [PDF]
ACS OmegaCarla Grosso +6 more
doaj +2 more sources