Results 41 to 50 of about 79,082 (160)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Lewis Acid Mediated Alkylation and Diels-Alder Reactions of 2H-Azirines

, 2002
This thesis describes the use of 2H-azirines as reactivesubstrates in Lewis acid catalysed nucleophilic additions andin the Diels-Alder reaction.A number of carbon nucleophiles have been added to aseries of 2H-azirines in the presence and absence ofBF3 ...
Risberg, Erik
core   +2 more sources

Lewis acid Mediated Aza-Diels-Alder Reactions and Asymmetric Alkylations of 2H-azirines [Elektronisk resurs]

, 2004
This thesis describes the use of 2H-azirines, three-membered unsaturatednitrogen-containing heterocycles, as reactive intermediates ina number of Lewis acid promoted alkylations and Diels-Alderreactions providing synthetically useful aziridines. In order
Risberg, Erik,
core   +4 more sources

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Investigation on the reactivity of α-azidochalcones with carboxylic acids: Formation of α-amido-1,3-diketones and highly substituted 2-(trifluoromethyl)oxazoles

Beilstein Journal of Organic Chemistry, 2015
The reaction of α-azidochalcones with carboxylic acids has been investigated resulting in the formation of α-amido-1,3-diketones under microwave irradiation via in situ formation of 2H-azirine intermediates.
Kandasamy Rajaguru, Arumugam Mariappan, Rajendran Suresh, Periasamy Manivannan, Shanmugam Muthusubramanian   +4 more
doaj   +1 more source

When Dark States Become Bright: Vibronic Intensity Borrowing in Triplet 2,6‐Dichloro‐4‐Hydroxyphenylnitrene

Journal of Physical Organic Chemistry, Volume 39, Issue 7, July 2026.
Irradiation of 4‐azido‐2,6‐dichlorophenol in cryogenic matrices generates triplet 2,6‐dichloro‐4‐hydroxyphenylnitrene. Vibronically structured absorption enables extension of a formally forbidden transition into the visible region (up to 500 nm). Analyses based on NICS(1.7)zz, ACID, HOMA, MCI, and spin density reveal magnetically induced ring currents ...
Dharma Raj Joshi, Anindya Borah, Dmitrii Govorov, Trevor Henry, Bruce S. Ault, Anna D. Gudmundsdottir   +5 more
wiley   +1 more source

Azirinium ylides from alkoxycarbonylcarbenoids and 2H-azirines: Generation and transformations

, 2006
Dirhodium tetraacetate-catalyzed decomposition of diazo esters in the presence of 3-aryl-2H-azirines having no substituent in the 2-position gives rise to azirinium ylides which then undergo isomerization into 2-azabuta-1,3-diene derivatives or (in the ...
Magull, Joerg, Amer, A. A., Novikov, M. S., Vidovic, D., Khlebnikov, Alexander F., Kostikov, Rafael R.   +5 more
core   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines [PDF]

Synlett, 2015
Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-substituted aziridines through a telescoped reaction sequence involving nitrile, trifluoromethyl, or ...
Baumann, Marcus, Baxendale, Ian R.
openaire   +3 more sources