Results 11 to 20 of about 1,013 (159)

Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones. [PDF]

Bioorg Med Chem, 2014
Myeloperoxidase (MPO) produces hypohalous acids as a key component of the innate immune response; however, release of these acids extracellularly results in inflammatory cell and tissue damage. The two-step, one-pot Davis-Beirut reaction was used to synthesize a library of 2H-indazoles and 1H-indazolones as putative inhibitors of MPO.
Roth A, Ott S, Farber KM, Palazzo TA, Conrad WE, Haddadin MJ, Tantillo DJ, Cross CE, Eiserich JP, Kurth MJ.   +9 more
europepmc   +6 more sources

Photochemical Conversion of Indazoles into Benzimidazoles. [PDF]

Angew Chem Int Ed Engl
We present a photochemical strategy for transforming 1H‐ and 2H‐indazoles into benzimidazoles, enabling heteroaromatic interconversion under mild conditions. This approach, grounded in a two‐step mechanism of excited‐state tautomerization and photochemical rearrangement, offers broad scope, high yields, and functional group tolerance, expanding the ...
Dos Santos T, Buettner CS, Yildiz DB, Mamone M, Ruffoni A, Leonori D.   +5 more
europepmc   +2 more sources

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

Beilstein Journal of Organic Chemistry, 2021
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient ...
Ryan M. Alam, John J. Keating
doaj   +1 more source

2-(4-Methylphenyl)-2H-indazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The title compound, C(14)H(12)N(2), was synthesized by the reaction of 4-methyl-N-(2-nitro-benz-yl)aniline with tin(II) chloride dihydrate in ethanol at 313 K. The indazole ring system is almost planar with a dihedral angle of 1.58 (10)° between the rings, whereas the plane of the attached p-tolyl substituent shows a dihedral angle of 46.26 (5)° with ...
Xingqin Zhou, Xiaofen Qin, Jiankang Zhang   +2 more
openaire   +3 more sources

2-(2H-Indazol-2-yl)-1-phenylethanone [PDF]

Acta Crystallographica Section E Structure Reports Online, 2013
The asymmetric unit of the title compound, C15H12N2O, contains two independent molecules with different conformations, the phenyl ring and indazole mean plane in the two molecules forming dihedral angles of 50.82 (5) and 89.29 (6)°. In the crystal, weak C—H...O and C–H...N hydrogen bonds and C—H...π interactions consolidate the packing.
Özel Güven, Özden, Türk, Gökhan, Adler, Philip D.F., Coles, Simon J., Hökelek, Tuncer   +4 more
openaire   +7 more sources

Rh(III)-catalyzed C–H acylmethylation of 2H-indazoles with sulfoxonium ylides

Journal of Saudi Chemical Society, 2020
An efficient Cp*Rh(III)-catalyzed direct acylmethylation of 2H-indazoles with sulfoxonium ylides has been realized under air atmosphere via chelation-assisted strategy.
Ya-Gai Wang, Jing Li, Xiao-Die Wang, Linlin Shi, Xinju Zhu, Xin-Qi Hao, Mao-Ping Song   +6 more
doaj   +1 more source

Davis–Beirut reaction inspired nitroso Diels–Alder reaction [PDF]

, 2021
A Davis–Beirut reaction inspired nitroso Diels–Alder protocol is reported. The starting material for the procedure is a nitrophenyl moiety with the para position appropriately substituted with a 2°-amine (see 5) or 2°-alcohol (see 6).
Cheung, Amy, Haddadin, Makhluf J., Kurth, Mark J., Son, Jung-Ho, Zhu, Jie S.   +4 more
core   +1 more source

Eco-Friendly, Green Approach for Synthesis of Bio-Active Novel 3-Aminoindazole Derivatives [PDF]

, 2021
In present chapter we have reported green and highly efficient method for synthesize novel series of substituted -1H-indazol-3-amine derivative (3a-h) by cyclocondensation reaction of substituted benzonitrile (1a-h) and substituted Hydrazine (2a-h) using
Devkate, Chandrashekhar, Idrees, Mohammad, Kola, Satish, Nasare, Roshan D., Siddiqui, Naqui J.   +4 more
core   +1 more source

2-Methyl-6-nitro-2H-indazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(8)H(7)N(3)O(2), the mol-ecular skeleton is almost planar with a maximum deviation of 0.0484 (9) Å for the methyl C atom. In the crystal, weak inter-molecular C-H⋯N and C-H⋯O hydrogen bonds help to establish the packing.
Li Long, Bing-Ni Liu, Mo Liu, Deng-Ke Liu   +3 more
openaire   +3 more sources

Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. [PDF]

, 2012
The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good ...
Andreas Unsinn, Batt, Bunnell, Bunnell, Chevallier, Clutterbuck, Collot, Crestey, Despotopoulou, Dong, Dunst, Farina, Fraile, Haag, Haag, Kienle, Knochel, Luo, Malamas, Mulvey, Negishi, Negishi, Negishi, Negishi, Negishi, Ohnmacht, Pabba, Paul Knochel, Perez, Peruncheralathan, Piazza, Pyne, Schmidt, Stadlbauer, Sun, Villieras, Welch, Whisler, Wunderlich, Wunderlich, Yang   +40 more
core   +1 more source