Results 51 to 60 of about 1,013 (159)

Photochemische Permutation von Indazolen zu Benzimidazolen

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Hier stellen wir eine photochemische Strategie für die direkte Permutation von 1H‐ und 2H‐Indazolen zu Benzimidazolen vor. Dieser Ansatz beruht auf einem zweistufigen Mechanismus aus Tautomerisierung im angeregten Zustand und photochemischer Umlagerung, bietet einen breiten Anwendungsbereich, hohe Ausbeuten und funktionelle Gruppentoleranz und erhöht ...
Thiago dos Santos, Cornelia S. Buettner, Dilara Berna Yildiz, Martina Mamone, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

Diazonium Salts in Visible Light Photocatalysis – a Focused Overview of their Application in Continuous Flow Synthesis

ChemPhotoChem, Volume 9, Issue 6, June 2025.
The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
wiley   +1 more source

N,N‐Bond‐Forming Heterocyclization: Synthesis of 3‐Alkoxy‐2H‐indazoles. [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aaron D. Mills, Musa Z. Nazer, Makhluf J. Haddadin, Mark J. Kurth   +3 more
openaire   +1 more source

In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

Drug Testing and Analysis, Volume 17, Issue 5, Page 701-712, May 2025.
Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio, Robin Obrist, Lucas Krebs, Therése Klingstedt, Johan Dahlén, Xiongyu Wu, Henrik Gréen   +6 more
wiley   +1 more source

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement [PDF]

, 2018
Herein we report the transformation of readily synthesised acyl hydrazides into 2-hydrazobenzophenones via a novel molecular rearrangement pathway using aryne chemistry. The developed reaction protocol is performed under relatively mild conditions and is
Chudasama, V, Shamsabadi, A
core  

Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
Hydrazide‐based derivatives were evaluated as inhibitors of human carbonic anhydrase (hCA) isoforms I, II, IV, IX, and XII. Several derivatives, particularly those with ureido‐linkers, exhibited strong inhibitory activity with inhibition constants in the low micromolar range.
German Benito Menendez, Simone Giovannuzzi, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran   +5 more
wiley   +1 more source

Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis–Beirut Reaction [PDF]

, 2017
The discovery of a new variation on the Davis-Beirut reaction is described in which an atypical heterocyclic framework (the anthranil or benzo[c]isoxazole framework) is formed as the result of diversion of a key reactive intermediate away from its ...
Haddadin, Makhluf J, Kurth, Mark J, Son, Jung-Ho, Tantillo, Dean J, Teuthorn, Andrew P, Zhu, Jie S   +5 more
core   +1 more source

Development of Potent Type V MAPK Inhibitors: Design, Synthesis, and Biological Evaluation of Benzothiazole Derivatives Targeting p38α MAPK in Breast Cancer Cells

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
Type V MAPK inhibitors are unique for targeting both ATP and allosteric sites. In silico analysis and experimental methods were combined to optimize benzothiazole derivatives for antiproliferative activity against breast cancer cells. Two compounds showed significant inhibition of p38α MAPK, suggesting promising anticancer potential.
Bayan Zoatier, K. Gizem Yildiztekin, M. Abdullah Alagoz, Ceylan Hepokur, Serdar Burmaoglu, Oztekin Algul   +5 more
wiley   +1 more source

Sustainable Approaches for the site-selective C-H Functionalization of 2H-Indazoles [PDF]

, 2019
Heterocyclic moieties are a prominent feature present in natural products, drug molecules and known for their various properties. Especially nitrogen heterocycles are of particular interest in medicinal chemistry, due to their diverse and significant ...
D S, Sharada, Murugan, A
core  

Frontmatter (Front Cover, Editorial Team, Indexing, and Table of Contents) [PDF]

, 2018
Frontmatter (Front Cover, Editorial Team, Indexing, and Table of ...
Istadi Istadi
core   +2 more sources