Results 121 to 130 of about 54,789 (273)

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Safety assessment of the substance poly((R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyhexanoate) for use in food contact materials

EFSA Journal, 2019
The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP Panel) assessed the safety of poly((R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyhexanoate) (PHBH), CAS No 147398‐31‐0 and food contact material (FCM) substance No 1059.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Beat Johannes Brüschweiler, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Alicja Mortensen, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Laurence Castle, Jean‐Pierre Cravedi, Roland Franz, Martine Kolf‐Clauw, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson, Maria de Fatima Tavares Poças, Detlef Wölfle, Katharina Volk, Gilles Rivière   +27 more
doaj   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2

生物医学转化
Objective To investigate the therapeutic effects and underlying mechanisms of the metabolite 3- hydroxybutyrate (3HB) in a cecal ligation and puncture (CLP)-induced sepsis model in mice.
Hu Jingjuan, Deng Fan, Sun Qishun, Min Yue, Feng Siyuan, Wu Ling, Chen Xiaofeng, Liu Kexuan   +7 more
doaj   +1 more source

Techno‐economic analysis for hydroxy acids production from waste cellulose via alkaline digestion

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Alkaline digestion offers a promising route for converting low‐grade cellulosic wastes into valuable hydroxy carboxylic acids (HAs). However, the feasibility of producing HAs at process scale, particularly the influence of reactor design on product yields, energy demand, and production costs, remains less explored.
Farangis Fallahmehneh, Massimiliano Errico, Kristian Melin, Tuomo Sainio   +3 more
wiley   +1 more source

Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

Frontiers in Nutrition
IntroductionThe brain uses ketones, mainly 3-hydroxybutyrate (3-HB), as an alternative energy source. Therefore, oral intake of 3-HB may help maintain brain health.
Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama   +12 more
doaj   +1 more source

Laboratory Research of Degradation of Polyhydroxyalkanoates of Different Chemical Structure in Soil [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2015
Degradation of three types of polyhydroxyalkanoates (PHAs) was studied in the laboratory conditions in the field soil at two temperature regimes during 35 days.
Olga N. Vinogradova, Daria A. Syrvacheva
doaj  

From Molecule to Material: How Support Changes Heterobimetallic Catalysts in Lactide Polymerization

Macromolecular Rapid Communications, EarlyView.
Silica‐supported heterobimetallic alkoxide complexes were developed as catalysts for lactide ring‐opening polymerization. Grafting iron‐based ate complexes onto SiO2‐700 produced well‐defined active sites, enabling controlled polymerization with predictable molar masses, narrow dispersities, and recyclability.
Fan Yang, Yahaya Nasiru, Abdulrahman Adamu Isah, Aimery de Mallmann, Mostafa Taoufik, Régis M. Gauvin, Christophe M. Thomas   +6 more
wiley   +1 more source

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech, Sarah L. Manske, Paul G. Mullins, Tiffany K. Bell, Ashley D. Harris   +4 more
wiley   +1 more source

Impact of Organic and Inorganic Fillers on the Performance of Ternary Biodegradable Poly(Butylene Succinate‐Co‐Butylene Adipate), Poly(Butylene Adipate‐Co‐Terephthalate), and Poly(3‐Hydroxybutyrate‐Co‐3‐Hydroxyvalerate) Blends

Polymer Composites, EarlyView.
Development of a ternary blend composite based on PBAT/PBSA/PHVB with improved mechanical properties. ABSTRACT This study explores a ternary biodegradable blend of bio‐based poly(butylene succinate‐co‐adipate) (bio‐PBSA), poly(butylene adipate terephthalate) (PBAT), and poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV).
Sasha Paquette, Matias Menossi, Ehsan Pesaranhajiabbas, Hamdy Khalil, Manjusri Misra, Amar Kumar Mohanty   +5 more
wiley   +1 more source