Results 111 to 120 of about 18,203,152 (258)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Pediatric hereditary angioedema presenting as recurrent episodic abdominal pain and vomiting: Challenges in diagnosis and management

JPGN Reports, EarlyView.
Abstract Recurrent episodic abdominal pain and vomiting, with symptom‐free intervals between attacks, represent common and often challenging presentations in children, typically leading to extensive workups without a clear etiology, as standard diagnostic algorithms fail to include rare systemic conditions. We present the challenging diagnostic odyssey
Julio Nestor Busaniche, Jhoanna Valery Adauto Luizaga, Maria Soledad Arcucci, Claudio Alberto Salvador Parisi, Judith Cohen Sabban, Agustina Venditti, Valentina Riveros, Giancarlo Testa, Veronica Busoni   +8 more
wiley   +1 more source

Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Self-Reinforced Composites via Solvent-Induced Interfiber Welding of Nanofibers

Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Self-Reinforced Composites via Solvent-Induced Interfiber Welding of ...
Shazed Aziz (3118941), Peter J Halley (19481953), Luigi-Jules Vandi (19481956), Tony McNally (3918062), Ton Peijs (1924303), Russell Varley (13092147), Pejman Heidarian (13072881)   +6 more
core  

Metabolomic insights for the authentication and traceability of antibiotic‐free pork: a pilot study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Antibiotic‐free production within the meat supply chain is a source of concern since new voluntary label claims need to be authenticated to prevent fraud. Therefore, an untargeted 1H NMR‐based metabolomics approach coupled to unsupervised (principal component analysis) and supervised (orthogonal partial least squares discriminant ...
Maria Olga Varrà, Maria Pia Fabrile, Sergio Ghidini, Augusta Caligiani, Federico Scali, Veronica Lolli, Giovanni Loris Alborali, Adriana Ianieri, Emanuela Zanardi   +8 more
wiley   +1 more source

Chemical synthesis of perfectly isotactic and high melting bacterial poly(3-hydroxybutyrate) from bio-sourced racemic cyclic diolide

Nature Communications, 2018
Bacterial poly(3-hydroxybutyrate) possesses physical and mechanical properties suitable for substituting high-performance petroleum plastics but current production is costly and slow.
Xiaoyan Tang, Eugene Y.-X. Chen
doaj   +1 more source

Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications

, 2010
Poly(3-hydroxybutyrate) (P(3HB)) foams exhibiting highly interconnected porosity (85% porosity) were prepared using a unique combination of solvent casting and particulate leaching techniques by employing commercially available sugar cubes as porogen ...
Misra, S.K., Boccaccini, A.R., Roy, I., Knowles, J.C., Philip, S.E., Stark, W.J., Salih, V., Ansari, T.I., Valappil, S.P., Mohn, D.   +9 more
core   +1 more source

Management of ketogenic diet therapy in patients with ileostomy: A report of 2 cases

Nutrition in Clinical Practice, EarlyView.
Abstract This case series explores the feasibility and clinical considerations of implementing the ketogenic diet therapy (KDT) for epilepsy management in patients with ileostomies. Two pediatric patients with medication‐resistant epilepsy and ileostomies continued KDT under clinical supervision.
Braden J. Baker, Abigail E. Olbina, Marissa A. Godfrey, Annie E. Graber, Taylor N. Parrish, Sarah Isis R. Delima   +5 more
wiley   +1 more source

D,L‐3‐hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS)

JIMD Reports
Background Deficiency of the Glut1 transporter due to mono‐allelic variants in SLC2A1 causes hypoglycorrhachia, resulting in a neurological spectrum from neonatal epilepsy to adult‐onset paroxysmal movement disorders (PMD).
Aya Amer, Kathryn Murrell, Liza Edmonds, Isaac Bernhardt, Rhonda Akroyd, Bryony Ryder, Callum Wilson, Emma Glamuzina   +7 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2

生物医学转化
Objective To investigate the therapeutic effects and underlying mechanisms of the metabolite 3- hydroxybutyrate (3HB) in a cecal ligation and puncture (CLP)-induced sepsis model in mice.
Hu Jingjuan, Deng Fan, Sun Qishun, Min Yue, Feng Siyuan, Wu Ling, Chen Xiaofeng, Liu Kexuan   +7 more
doaj   +1 more source