Results 1 to 10 of about 5,325,641 (318)
Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling [PDF]
Frontiers in Molecular Neuroscience, 2021 Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological conditions such as diabetes.
Darío García-Rodríguez +1 more
doaj +6 more sources
Measuring ketone bodies for the monitoring of pathologic and therapeutic ketosis [PDF]
Obesity Science & Practice, 2021 Background The ketone bodies β‐hydroxybutyrate (BOHB) and acetone are generated as a byproduct of the fat metabolism process. In healthy individuals, ketone body levels are ∼0.1 mM for BOHB and ∼1 part per million for breath acetone (BrAce). These levels
Joseph C. Anderson +3 more
doaj +3 more sources
Ketone Bodies in Diabetes Mellitus: Friend or Foe? [PDF]
Nutrients, 2023 In glucose-deprived conditions, ketone bodies are produced by the liver mitochondria, through the catabolism of fatty acids, and are used peripherally, as an alternative energy source.
Veneti S +4 more
europepmc +4 more sources
Ketone bodies: A double-edged sword for mammalian life span. [PDF]
Aging Cell, 2023 Accumulating evidence suggests health benefits of ketone bodies, and especially for longevity. However, the precise role of endogenous ketogenesis in mammalian life span, and the safety and efficacy of the long‐term exogenous supplementation of ketone ...
Tomita I +11 more
europepmc +5 more sources
Ketone bodies: from enemy to friend and guardian angel
BMC Medicine, 2021 During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the major source of energy.
Hubert Kolb +5 more
doaj +2 more sources
Archives of Medical Science – Atherosclerotic Diseases, 2021 Ketone bodies are low chain organic substances with four carbon atoms, with β-hydroxybutyric acid and acetone being the main ketone bodies in blood circulation. Under physiological conditions their levels are low while during conditions of oxidative stress, such as exercise, fasting state and acute illness, ketone body levels are increased.
Papazafiropoulou, Athanasia K. +2 more
openaire +3 more sources
Regulation of adult stem cell function by ketone bodies [PDF]
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore
Ole Emil Andersen +5 more
doaj +2 more sources
Circulating ketone bodies and cardiovascular outcomes: the MESA study. [PDF]
Eur Heart J, 2023 AIMS Ketone bodies (KB) are an important alternative metabolic fuel source for the myocardium. Experimental and human investigations suggest that KB may have protective effects in patients with heart failure.
Shemesh E +12 more
europepmc +2 more sources
Fasting Ketone Bodies and Incident Type 2 Diabetes in the General Population. [PDF]
Diabetes, 2023 With rising incidence and prevalence of type 2 diabetes, prevention including identification of prospective biomarkers becomes increasingly relevant. Although ketone bodies recently received a renewed interest as potential biomarkers, data linking these ...
Szili-Torok T +7 more
europepmc +2 more sources
Ketone Bodies in Cardiovascular Disease [PDF]
JACC: Basic to Translational ScienceSummary: Evidence for the potential of ketone bodies (KBs) in the treatment of cardiovascular disease is growing rapidly. In addition to serving as sources of myocardial fuel, KBs exert an array of pleiotropic activities via multiple mechanisms.
Azariyas A. Challa, MD, PhD +4 more
doaj +2 more sources