Results 21 to 30 of about 57,304 (300)
Ketone bodies: from enemy to friend and guardian angel
BMC Medicine, 2021 During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the major source of energy.
Hubert Kolb +5 more
doaj +1 more source
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy [PDF]
, 2011 Background: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect.
Maurer, Gabriele D. +8 more
core +1 more source
Archives of Medical Science – Atherosclerotic Diseases, 2021 Ketone bodies are low chain organic substances with four carbon atoms, with β-hydroxybutyric acid and acetone being the main ketone bodies in blood circulation. Under physiological conditions their levels are low while during conditions of oxidative stress, such as exercise, fasting state and acute illness, ketone body levels are increased.
Papazafiropoulou, Athanasia K. +2 more
openaire +2 more sources
Molecular Metabolism, 2021 Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents.
David B. Stagg +6 more
doaj +1 more source
Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation. [PDF]
, 2016 Ketone bodies have been shown to transiently stimulate food intake and modify energy homeostasis regulatory systems following cerebral infusion for a moderate period of time (<6 hours). As ketone bodies are usually enhanced during episodes of fasting,
Carneiro, L. +6 more
core +4 more sources
Ketogenic diet versus ketoacidosis: what determines the influence of ketone bodies on neurons?
Neural Regeneration Research, 2018 Glucose is the main energy substrate for neurons, however, at certain conditions, e.g. in starvation, these cells could also use ketone bodies. This approach is used in clinical conditions as the ketogenic diet.
Sergei V Fedorovich +2 more
doaj +1 more source
Ketone bodies as signaling metabolites [PDF]
Trends in Endocrinology & Metabolism, 2014 Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link
John C, Newman, Eric, Verdin
openaire +2 more sources
Determination of 14C radioactivity in ketone bodies: a new, simplified method and its validation.
Journal of Lipid Research, 1980 A rapid and reproducible method for the assay of 14C radioactivity in ketone bodies is described, based on the heat lability of acetoacetate and the ability of beta-hydroxybutyrate to quantitatively bind to and elute from an ion exchange resin. Potential
J M Miles +3 more
doaj +1 more source
Food Chemistry: Molecular Sciences, 2021 Ketogenic diets consist of low carbohydrate/high fat, shifting energy reliance from glucose to ketone bodies. Ketone diester supplement to a standard diet (ketone ester) increases ketone bodies by adding a substance without altering other consumed foods.
LT Claire M. Modica +6 more
doaj +1 more source
Ketone Bodies, Potential Therapeutic Uses [PDF]
IUBMB Life, 2001 AbstractKetosis, meaning elevation of D‐ β‐hydroxybutyrate ( R ‐3‐hydroxybutyrate) and acetoacetate, has been central to starving man's survival by providing nonglucose substrate to his evolutionarily hypertrophied brain, sparing muscle from destruction for glucose synthesis.
R L, Veech +4 more
openaire +2 more sources