Results 31 to 40 of about 5,325,641 (318)

Ketone bodies in epilepsy [PDF]

Journal of Neurochemistry, 2012
J. Neurochem.(2012)121, 28–35.AbstractSeizures that are resistant to standard medications remain a major clinical problem. One underutilized option for patients with medication‐resistant seizures is the high‐fat, low‐carbohydrate ketogenic diet. The diet received its name based on the observation that patients consuming this diet produce ketone bodies (
Melanie A, McNally, Adam L, Hartman
openaire   +2 more sources

Ketone bodies : back to a place in the sun. [PDF]

, 2021
Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation
久米, 真司, 00452235, KUME, Shinji, 1869, 0000-0001-6937-9715   +4 more
core   +1 more source

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

Annual review of nutrition, 2021
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and
Patrycja Puchalska, P. Crawford
semanticscholar   +1 more source

Ketone body oxidation increases cardiac endothelial cell proliferation

EMBO Molecular Medicine, 2022
Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essential substrates for ATP and biomass production; however, the metabolism of other substrates remains poorly understood.
Eva‐Maria Weis, Patrycja Puchalska, Alisa B Nelson, Jacqueline Taylor, Iris Moll, Sana S Hasan, Matthias Dewenter, Marco Hagenmüller, Thomas Fleming, Gernot Poschet, Agnes Hotz‐Wagenblatt, Johannes Backs, Peter A Crawford, Andreas Fischer   +13 more
doaj   +1 more source

Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation

Nature Metabolism, 2022
During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity ...
Bryon Silva, O. L. Mantha, J. Schor, Alberto Pascual, P. Plaçais, A. Pavlowsky, T. Préat   +6 more
semanticscholar   +1 more source

Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2023
Background Pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) are debilitating diseases with a high mortality. Despite emerging treatments, pulmonary vascular resistance frequently remains elevated.
R. Nielsen, K. H. Christensen, N. Gopalasingam, K. Berg-Hansen, J. Seefeldt, C. Homilius, E. Boedtkjer, M. Andersen, H. Wiggers, Niels Møller, H. Bøtker, Søren Mellemkjær   +11 more
semanticscholar   +1 more source

Ketogenic effects of medium chain triglycerides containing formula and its correlation to breath acetone in healthy volunteers: a randomized, double-blinded, placebo-controlled, single dose-response study

Frontiers in Nutrition, 2023
The efficacy of low-carbohydrate, high-fat diets, such as ketogenic diets, for cancer patients is of research interest. We previously demonstrated the efficacy of the ketogenic diet in a case study in which medium-chain triglycerides (MCTs) or MCT ...
Kentaro Nakamura, Keisuke Hagihara, Naoko Nagai, Ryuichiro Egashira, Mariko Takeuchi, Mai Nakano, Hitomi Saito, Misaki Moriguchi, Satoko Tonari, Hisako Fujii, Akimitsu Miyake, Yusuke Omae, Kinya Ashida   +12 more
doaj   +1 more source

Effects of ketone bodies on energy expenditure, substrate utilization, and energy intake in humans

Journal of Lipid Research, 2023
The potential of ketogenic approaches to regulate energy balance has recently gained attention since ketones may influence both energy expenditure and energy intake.
R. Fernández-Verdejo, J. Mey, E. Ravussin   +2 more
semanticscholar   +1 more source

Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC Focus Seminar.

Journal of the American College of Cardiology, 2021
Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical stigma as they are involved in diabetic ketoacidosis.
Salva R. Yurista, Cher-Rin Chong, J. Badimón, D. Kelly, Rudolf A. de Boer, B. Westenbrink   +5 more
semanticscholar   +1 more source

Ketone bodies as signaling metabolites [PDF]

Trends in Endocrinology & Metabolism, 2014
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link
John C, Newman, Eric, Verdin
openaire   +2 more sources