Results 31 to 40 of about 815,133 (291)

Cardiac ketone body metabolism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020
The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds derived principally from fatty acids, that can be metabolised by many oxidative tissues, including heart, in carbohydrate-depleted conditions as glucose-sparing energy substrates.
Azrul, Abdul Kadir, Kieran, Clarke, Rhys D, Evans   +2 more
openaire   +2 more sources

INHIBITION OF PARAOXONASE1 BY KETONE BODIES: AN INVITRO STUDY [PDF]

, 2013
Objective: In uncontrolled diabetes mellitus, concentration of ketone bodies is elevated to up to 25mM. This study aims to investigate the inhibitory action of ketone bodies on paraoxonase and arylesterase (ARE\u27ase) activity of Paraoxonase1 (PON1 ...
RICHARD S, AUSTIN, J M D’SOUZA, CLETUS
core   +2 more sources

Pathophysiological Abnormalities in Migraine Ameliorated by Ketosis: A Proof-of-Concept Review

Journal of Integrative Neuroscience, 2022
Migraine is a prevalent heterogeneous neurological disorder, enumerated as the eighth most disabling neurological disorder by the World Health Organization.
Panitda Huynh, Pasquale Calabrese
doaj   +1 more source

1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine

, 1986
High-resolution 1H NMR spectroscopy has been applied to a study of urine from five normal human subjects during a 48-h period of fasting and for 22 h thereafter.
Sadler, P.J., Nicholson, J.K., Bales, J.R., Bell, J.D.   +3 more
core   +1 more source

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms

Frontiers in Neurology, 2019
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation and usually produced in fasting state or on high-fat diets have broad neuroprotective effects.
Huajun Yang, Huajun Yang, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Fei Zhu, Fei Zhu, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang, Qun Wang   +14 more
doaj   +1 more source

Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

Frontiers in Psychiatry, 2023
In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment ...
Naomi Elyse Omori, Mantas Kazimieras Malys, Geoffrey Woo, Latt Mansor   +3 more
doaj   +1 more source

ketone bodies-html

, 2014
unigenes associated with synthesis and degradation of ketone bodies  
Karen Fugate (480954)
core   +1 more source

ketone bodies-png

, 2014
unigenes associated with synthesis and degradation of ketone ...
Karen Fugate (480954)
core   +1 more source

Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle

Cardiovascular Therapeutics
Ketone bodies can serve as energy substrates for the heart and perform important molecular signal transduction functions. In recent years, the therapeutic potential of ketone bodies has become a research hotspot in the field of cardiovascular diseases ...
Lei Li, Xiaojian Song, Xiurui Ma, Yanwu Xu   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source