Results 11 to 20 of about 5,325,641 (318)
Nonalcoholic fatty liver disease, circulating ketone bodies and all‐cause mortality in a general population‐based cohort [PDF]
European Journal of Clinical Investigation, 2021 Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of NAFLD.
Adrian Post +2 more
exaly +4 more sources
Oxaloacetate and Ketone Bodies Synergistically Promote Myoblast Differentiation in L6 Cells [PDF]
MoleculesMalnutrition and aging are major factors that inhibit myoblast differentiation, leading to a decline in muscle function and contributing to sarcopenia development.
Yuji Onuki +4 more
doaj +4 more sources
Ketone bodies for the failing heart: fuels that can fix the engine? [PDF]
Trends in Endocrinology and Metabolism, 2021 Accumulating evidence suggests that the failing heart reverts energy metabolism toward increased utilization of ketone bodies. Despite many discrepancies in the literature, evidence from both bench and clinical research demonstrates beneficial effects of
Anthony Rosenzweig, Salva R Yurista
exaly +4 more sources
Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders
Frontiers in Psychiatry, 2023 In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment ...
Naomi Elyse Omori +3 more
doaj +2 more sources
Ketone Bodies Mediate Antiseizure Effects [PDF]
Pediatric Neurology Briefs, 2015 Investigators from The Barrow Neurological Institute, Creighton University, University of Kentucky and the University of Calgary Faculty of Medicine investigated the effect of ketone bodies and the ketogenic diet on epileptic Kcna1-null mice.
Jena M. Krueger, Douglas R. Nordli
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the
Sebastian Niezen +8 more
doaj +2 more sources
Nutrients, 2020 Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced by the liver from fatty acids during periods of fasting, and prolonged or
Luciano Pirola +2 more
exaly +2 more sources
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases
International Journal of Molecular Sciences, 2020 Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain.
Nicole Jensen +2 more
exaly +2 more sources
Viruses, 2023 One of the proposed nutritional therapies to support drug therapy in COVID-19 is the use of a ketogenic diet (KD) or ketone bodies. In this review, we summarized the evidence from tissue, animal, and human models and looked at the mechanisms of action of
Izabela Bolesławska +3 more
doaj +3 more sources
Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms
Frontiers in Neurology, 2019 There is growing evidence that ketone bodies, which are derived from fatty acid oxidation and usually produced in fasting state or on high-fat diets have broad neuroprotective effects.
Huajun Yang +14 more
doaj +2 more sources