Results 11 to 20 of about 845,184 (295)
Measuring ketone bodies for the monitoring of pathologic and therapeutic ketosis
Obesity Science & Practice, 2021 Background The ketone bodies β‐hydroxybutyrate (BOHB) and acetone are generated as a byproduct of the fat metabolism process. In healthy individuals, ketone body levels are ∼0.1 mM for BOHB and ∼1 part per million for breath acetone (BrAce). These levels
Joseph C. Anderson +3 more
doaj +3 more sources
Ketone Bodies Mediate Antiseizure Effects
Pediatric Neurology Briefs, 2015 Investigators from The Barrow Neurological Institute, Creighton University, University of Kentucky and the University of Calgary Faculty of Medicine investigated the effect of ketone bodies and the ketogenic diet on epileptic Kcna1-null mice.
Jena M. Krueger, Douglas R. Nordli
doaj +2 more sources
Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling [PDF]
Frontiers in Molecular Neuroscience, 2021 Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological conditions such as diabetes.
Darío García-Rodríguez +1 more
doaj +2 more sources
Viruses, 2023 One of the proposed nutritional therapies to support drug therapy in COVID-19 is the use of a ketogenic diet (KD) or ketone bodies. In this review, we summarized the evidence from tissue, animal, and human models and looked at the mechanisms of action of
Izabela Bolesławska +3 more
doaj +2 more sources
Molecular MetabolismObjective: Ketone bodies (such as β-hydroxybutyrate or BHB) have been recently proposed as signals involved in brain regulation of energy homeostasis and obesity development. However, the precise role of ketone bodies sensing by the brain, and its impact
Lionel Carneiro +4 more
doaj +2 more sources
Ketone bodies in epilepsy [PDF]
Journal of Neurochemistry, 2012 J. Neurochem.(2012)121, 28–35.AbstractSeizures that are resistant to standard medications remain a major clinical problem. One underutilized option for patients with medication‐resistant seizures is the high‐fat, low‐carbohydrate ketogenic diet. The diet received its name based on the observation that patients consuming this diet produce ketone bodies (
Melanie A, McNally, Adam L, Hartman
openaire +2 more sources
Ketone body oxidation increases cardiac endothelial cell proliferation
EMBO Molecular Medicine, 2022 Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essential substrates for ATP and biomass production; however, the metabolism of other substrates remains poorly understood.
Eva‐Maria Weis +13 more
doaj +1 more source
Frontiers in Nutrition, 2023 The efficacy of low-carbohydrate, high-fat diets, such as ketogenic diets, for cancer patients is of research interest. We previously demonstrated the efficacy of the ketogenic diet in a case study in which medium-chain triglycerides (MCTs) or MCT ...
Kentaro Nakamura +12 more
doaj +1 more source
Ketone bodies as signaling metabolites [PDF]
Trends in Endocrinology & Metabolism, 2014 Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link
John C, Newman, Eric, Verdin
openaire +2 more sources
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy [PDF]
, 2011 Background: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect.
Stefan Walenta +26 more
core +2 more sources