Results 181 to 190 of about 18,900,322 (326)

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, EarlyView.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

Engineering of <i>Escherichia coli</i> for Co-Production of Lignocellulosic Ethanol and Poly(3-hydroxybutyrate). [PDF]

Microorganisms
Luu NL, Liu YZ, Ta DT, Chiang CJ, Chao YP.   +4 more
europepmc   +1 more source

Optimizing Carbon Sources in Biofloc Technology for Sustainable Aquaculture: A Meta‐Analytical Review

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT Aquaculture intensification is increasingly constrained by high water demand, nutrient‐rich effluents and disease risk, increasing interest in biofloc technology (BFT) as a waste‐recycling, low‐exchange production model. However, BFT performance depends strongly on the carbon source used to adjust the carbon‐to‐nitrogen (C/N) ratio and ...
Mavindu Muthoka, Esther Magondu, Markose Zewdie, Douglas Okemwa, Domitila Kyule, Jonathan Munguti, Erick Ogello   +6 more
wiley   +1 more source

Temperature Dependence of Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyhexanoate) Biodegradation in Agricultural Soils. [PDF]

Environ Sci Technol
Laszakovits JR, Arn S, Kägi R, Liechti S, Wille F, McNeill K, Sander M.   +6 more
europepmc   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1192-1203, June 2026.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Process optimisation and genomic analysis of poly(3-hydroxybutyrate) production by Mycolicibacterium smegmatis using sugarcane bagasse. [PDF]

Bioresour Bioprocess
Hassan S, Krohn C, Aguilar G, Marshall A, Ball AS.   +4 more
europepmc   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Sodium glucose cotransporter‐2 (SGLT2) inhibitors are a class of antidiabetics with benefits including HbA1c‐lowering, weight loss, cardiovascular and renal protection in addition to adverse effects including genitourinary tract infections, ketoacidosis, and bone loss.
May E. Montasser, Salma A. Bargal, Elizabeth A. Streeten, Hilary B. Whitlatch, Zhinous Shahidzadeh Yazdi, Jordin Sirody, Rosanna Kiplagat, Merna Beshara, Jeffrey R. O’Connell, Simeon I. Taylor, Amber L. Beitelshees   +10 more
wiley   +1 more source

Functional and Mechanistic Insights of 3-Hydroxybutyrate (3-OBA) in Bladder Cancer. [PDF]

Molecules
Silva A, Félix AM, Gonçalves CS, Longatto-Filho A, Baltazar F, Afonso J.   +5 more
europepmc   +1 more source

Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4671-4682, June 2026.
ABSTRACT Introduction Oxytocin is expressed throughout the small intestine, suggesting a role for oxytocin in postprandial metabolism. Accordingly, single‐dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on ad libitum food intake, appetite sensations ...
Ida M. Gether, Vivian Kliim‐Hansen, Petur T. Olafsson, Miriam G. Pedersen, Casper K. Nielsen, Anne‐Marie Ellegaard, Mikkel B. Christensen, Jens F. Rehfeld, Jørn W. Helge, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +13 more
wiley   +1 more source