Results 1 to 10 of about 32 (32)

Exogenous 3-Iodothyronamine (T₁AM) Can Affect Phosphorylation of Proteins Involved on Signal Transduction Pathways in In Vitro Models of Brain Cell Lines, but These Effects Are Not Strengthened by Its Catabolite, 3-Iodothyroacetic Acid (TA₁)

Life, 2022
T1AM, a derivative of thyroid hormones, and its major catabolite, TA1, produce effects on memory acquisition in rodents. In the present study, we compared the effects of exogenous T1AM and TA1 on protein belonging to signal transduction pathways ...
Lavinia Bandini, Ginevra Sacripanti, Marco Borsò, Maria Tartaria, Maria Pia Fogliaro, Giulia Giannini, Vittoria Carnicelli, Matteo Emanuele Figuccia, Sara Verlotta, Fiammetta De Antoni, Riccardo Zucchi, Sandra Ghelardoni   +11 more
doaj   +1 more source

Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study

Molecules, 2021
Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by ...
Nicoletta di Leo, Stefania Moscato, Marco Borso', Simona Sestito, Beatrice Polini, Lavinia Bandini, Agostina Grillone, Matteo Battaglini, Alessandro Saba, Letizia Mattii, Gianni Ciofani, Grazia Chiellini   +11 more
doaj   +1 more source

Reversibility of Thyroid Hormone System–Disrupting Effects on Eye and Thyroid Follicle Development in Zebrafish (Danio rerio) Embryos

Environmental Toxicology and Chemistry, Volume 42, Issue 6, Page 1276-1292, June 2023., 2023
Abstract Early vertebrate development is partially regulated by thyroid hormones (THs). Environmental pollutants that interact with the TH system (TH system–disrupting chemicals [THSDCs]) can have massively disrupting effects on this essential phase. Eye development of fish is directly regulated by THs and can, therefore, be used as a thyroid‐related ...
Pauline Pannetier, Rikke Poulsen, Lisa Gölz, Sara Coordes, Hanna Stegeman, Johannes Koegst, Luisa Reger, Thomas Braunbeck, Martin Hansen, Lisa Baumann   +9 more
wiley   +1 more source

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Integrated Environmental Assessment and Management, Volume 19, Issue 1, Page 63-82, January 2023., 2023
Abstract This review examines the presence and evolution of thyroid‐like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing.
Jane E. Morthorst, Henrik Holbech, Noémie De Crozé, Peter Matthiessen, Gerald A. LeBlanc   +4 more
wiley   +1 more source

A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes. [PDF]

PLoS ONE, 2017
Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH ...
Keith H Richards, Nancy Schanze, Ray Monk, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle   +5 more
doaj   +1 more source

Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1)

Frontiers in Cellular Neuroscience, 2019
3-iodothyroacetic acid (TA1), an end metabolite of thyroid hormone, has been shown to produce behavioral effects in mice that are dependent on brain histamine.
Annunziatina Laurino, Elisa Landucci, Lorenzo Cinci, Manuela Gencarelli, Gaetano De Siena, Lorenza Bellusci, Grazia Chiellini, Laura Raimondi   +7 more
doaj   +1 more source

Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases

Frontiers in Endocrinology, 2018
3-Iodothyronamine (T1AM) is the last iodinated thyronamine generated from thyroid hormone alternative metabolism found circulating in rodents and in humans. So far, the physiopathological meaning of T1AM tissue levels is unknown. Much is instead known on
Annunziatina Laurino, Elisa Landucci, Laura Raimondi   +2 more
doaj   +1 more source

Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue

Frontiers in Cellular Neuroscience, 2019
Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion.
Elisa Landucci, Annunziatina Laurino, Lorenzo Cinci, Manuela Gencarelli, Laura Raimondi   +4 more
doaj   +1 more source

Thyroid Hormone and Wound Healing

Journal of Thyroid Research, Volume 2013, Issue 1, 2013., 2013
Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone.
Joshua D. Safer, Constantinos Pantos
wiley   +1 more source

TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis

Journal of Thyroid Research, Volume 2012, Issue 1, 2012., 2012
This paper provides the reader with an overview of our current knowledge of hypothalamic‐pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical ...
Johannes W. Dietrich, Gabi Landgrafe, Elisavet H. Fotiadou, Rudolf Hoermann   +3 more
wiley   +1 more source