3-Iodothyronamine Affects Thermogenic Substrates’ Mobilization in Brown Adipocytes [PDF]
Biology, 2020 We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were exposed to an adipogenic medium containing insulin in the absence (M) or ...
Manuela Gencarelli +6 more
doaj +11 more sources
Update on 3-iodothyronamine and its neurological and metabolic actions [PDF]
Frontiers in Physiology, 2014 3-iodothyronamine (T1AM) is an endogenous amine, that has been detected many rodent tissues, and in human blood. It has been hypothesized to derive from thyroid hormone metabolism, but this hypothesis still requires validation.
Riccardo eZucchi +2 more
doaj +7 more sources
Uptake of 3-iodothyronamine hormone analogs inhibits the growth and viability of cancer cells [PDF]
FEBS Open Bio, 2017 3‐Iodothyronamine (T1AM) is a structural analog of thyroid hormone that has been demonstrated to have potent affects on numerous physiological systems.
Lauren Gollahon, Fariba M Assadi-Porter
exaly +4 more sources
3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8? [PDF]
Frontiers in Endocrinology, 2017 The decarboxylated and deiodinated thyroid hormone (TH) derivative, 3-iodothyronamine (3-T1AM), is suggested to be involved in energy metabolism and thermoregulation.
Noushafarin Khajavi +2 more
doaj +4 more sources
TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells [PDF]
Frontiers in Pharmacology, 2018 In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization.
Lia Walcher +10 more
doaj +4 more sources
Exogenous 3-Iodothyronamine (T1AM) Can Affect Phosphorylation of Proteins Involved on Signal Transduction Pathways in In Vitro Models of Brain Cell Lines, but These Effects Are Not Strengthened by Its Catabolite, 3-Iodothyroacetic Acid (TA1) [PDF]
Life, 2022 T1AM, a derivative of thyroid hormones, and its major catabolite, TA1, produce effects on memory acquisition in rodents. In the present study, we compared the effects of exogenous T1AM and TA1 on protein belonging to signal transduction pathways ...
Lavinia Bandini +11 more
doaj +2 more sources
Thyroxine metabolite-derived 3-iodothyronamine (T1AM) and synthetic analogs as efficient suppressors of transthyretin amyloidosis [PDF]
Computational and Structural Biotechnology Journal, 2023 Aggregation and fibrillization of transthyretin (TTR) is a fatal pathogenic process that can cause cardiomyopathic and polyneuropathic diseases in humans.
Bokyung Kim +6 more
doaj +2 more sources
Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM). [PDF]
Biomed Res Int, 2020 Background. The thyroid hormone metabolite 3‐iodothyronamine (3‐T1AM) is rapidly emerging as a promising compound in decreasing the heart rate and lowering the cardiac output. The aim of our study was to fully understand the molecular mechanism of 3‐T1AM on cardiomyocytes and its potential targets in cardiovascular diseases. Materials and Methods.
Haiyan Z +4 more
europepmc +2 more sources
Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes [PDF]
Scientific Reports, 2022 There is growing interest in 3-iodothyronamine (T1AM), an active thyroid hormone metabolite, that induces negative inotropic and chronotropic actions in the heart and exerts systemic hypothermic action.
Hirotake Takahashi +9 more
doaj +2 more sources
Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6 [PDF]
Molecules, 2020 3-iodothyronamine (T1AM) and the recently developed analog SG-2 are rapidly emerging as promising multi-target neuroprotective ligands able to reprogram lipid metabolism and to produce memory enhancement in mice.
Lorenza Bellusci +11 more
doaj +2 more sources