Modulating Liver Cholesterol Metabolism by 3-Iodothyronamine
İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 2017 In this study, we attempt to find out whether chronic low dose 3-Iodothyronamine (an endogenous metabolite of thyroid hormone) administration could modulate liver de novo cholesterol synthesis, the same as thyroid hormones.
Nasrin KAZEMIPOUR +3 more
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Optical imaging of mitochondrial redox state in rodent models with 3-iodothyronamine [PDF]
Experimental Biology and Medicine, 2014 This study used an optical technique to measure the effects of treating low (10 mg/kg) and high (25 mg/kg) doses of 3-iodothyronamine (T 1 AM) on the metabolism in the kidney and heart of mice. The ratio of two intrinsic fluorophores in tissue, (NADH/FAD), called the NADH redox ratio (NADH RR)
Fariba M Assadi-Porter +2 more
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Modulation of cardiac ionic homeostasis by 3-iodothyronamine [PDF]
Journal of Cellular and Molecular Medicine, 2009 Abstract3‐iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone, able to interact with trace amine‐associated receptors, a class of plasma membrane G protein‐coupled receptors, and to produce a negative inotropic and chronotropic effect.
Elisabetta Cerbai +2 more
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Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases [PDF]
Frontiers in Endocrinology, 2018 3-Iodothyronamine (T1AM) is the last iodinated thyronamine generated from thyroid hormone alternative metabolism found circulating in rodents and in humans. So far, the physiopathological meaning of T1AM tissue levels is unknown. Much is instead known on
Annunziatina Laurino +2 more
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Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5. [PDF]
PLoS ONE, 2015 ObjectiveApplication of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still
Juliane Dinter +12 more
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3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines [PDF]
Frontiers in Endocrinology, 2018 3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to ...
Julia Bräunig +13 more
doaj +6 more sources
Commentary: 3-Iodothyronamine Reduces Insulin Secretion In Vitro via a Mitochondrial Mechanism [PDF]
Frontiers in Endocrinology, 2018 Lehmphul et al. report the effect of 3-iodothyronamine in reducing insulin release in a model of immortalized pancreatic β-cells. Notwithstanding the simplified β-cell model used, this article offers an opportunity to reconsider, possibly under a new ...
Annunziatina Laurino, Laura Raimondi
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Modulation of gene expression by 3-iodothyronamine: genetic evidence for a lipolytic pattern. [PDF]
PLoS ONE, 2014 3-Iodothyronamine (T1AM) is an endogenous biogenic amine, structurally related to thyroid hormone, which is regarded as a novel chemical messenger. The molecular mechanisms underlying T1AM effects are not known, but it is possible to envisage changes in ...
Veronica Mariotti +10 more
doaj +5 more sources
3-Iodothyronamine and Derivatives: New Allies Against Metabolic Syndrome? [PDF]
International Journal of Molecular Sciences, 2020 In the two decades since its discovery, a large body of evidence has amassed to highlight the potential of 3-iodothyronamine (T1AM) as an antiobesity drug, whose pleiotropic signaling actions profoundly impact energy metabolism. In the present review, we
Grazia Rutigliano +2 more
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3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice [PDF]
British Journal of Pharmacology, 2012 BACKGROUND AND PURPOSE Preclinical pharmacology of 3‐iodothyronamine (T1AM), an endogenous derivative of thyroid hormones, indicates that it is a rapid modulator of rodent metabolism and behaviour. Since T1AM undergoes rapid enzymatic degradation, particularly by MAO, we hypothesized that the effects of T1AM might be altered by inhibition of MAO ...
Grazia Chiellini +2 more
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