Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6 [PDF]
Molecules, 2020 3-iodothyronamine (T1AM) and the recently developed analog SG-2 are rapidly emerging as promising multi-target neuroprotective ligands able to reprogram lipid metabolism and to produce memory enhancement in mice.
Francesco Fornai +2 more
exaly +8 more sources
Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues. [PDF]
MoleculesAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder involving metabolic impairment, neuroinflammation, synaptic failure, and comorbidities.
Rosarita D'Orsi +2 more
exaly +4 more sources
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection [PDF]
Frontiers in Pharmacology, 2017 3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain.
Lorenza Bellusci +13 more
doaj +8 more sources
Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration [PDF]
Breast Cancer: Targets and Therapy, 2019 Eileen Tremmel,1 Simone Hofmann,1 Christina Kuhn,1 Helene Heidegger,1 Sabine Heublein,2 Kerstin Hermelink,1 Rachel Wuerstlein,1 Nadia Harbeck,1 Doris Mayr,3 Sven Mahner,1 Nina Ditsch,1 Udo Jeschke,1 Aurelia Vattai1 1Breast Center, Department of ...
Tremmel E +12 more
doaj +6 more sources
Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? [PDF]
Frontiers in Endocrinology, 2023 We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) in the adult brain.
Joseph V. Martin, Pradip K. Sarkar
doaj +2 more sources
Thyroxine metabolite-derived 3-iodothyronamine (T1AM) and synthetic analogs as efficient suppressors of transthyretin amyloidosis [PDF]
Computational and Structural Biotechnology Journal, 2023 Aggregation and fibrillization of transthyretin (TTR) is a fatal pathogenic process that can cause cardiomyopathic and polyneuropathic diseases in humans.
Bokyung Kim +6 more
doaj +2 more sources
Unveiling the nongenomic actions of thyroid hormones in adult mammalian brain: The legacy of Mary B. Dratman [PDF]
Frontiers in Endocrinology, 2023 A comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain.
Nilkanta Chakrabarti +4 more
doaj +2 more sources
Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline [PDF]
AntioxidantsThe release of reactive oxygen species accompanying oxidative stress is one of the most significant damaging mechanisms during brain ischemia. Some aspects of the neuroprotective activity of the thyronamine T0AM synthetic analogue, 4-[4-(2-aminoethoxy ...
Dmitry A. Filimonov +7 more
doaj +2 more sources
Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children. [PDF]
Pediatr Allergy Immunol, 2021 Abstract Background Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to under‐diagnosis. MicroRNAs (miRNA) regulate physiologic and pathologic processes, and they have been postulated as promising diagnostic markers.
Nuñez-Borque E +14 more
europepmc +2 more sources
Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases [PDF]
Frontiers in Endocrinology, 2018 3-Iodothyronamine (T1AM) is the last iodinated thyronamine generated from thyroid hormone alternative metabolism found circulating in rodents and in humans. So far, the physiopathological meaning of T1AM tissue levels is unknown. Much is instead known on
Annunziatina Laurino +2 more
doaj +2 more sources