Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study [PDF]
Molecules, 2021 Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by ...
Grazia Chiellini +2 more
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Molecules important for thyroid hormone synthesis and action - known facts and future perspectives [PDF]
Thyroid Research, 2011 Thyroid hormones are of crucial importance for the functioning of nearly every organ. Remarkably, disturbances of thyroid hormone synthesis and function are among the most common endocrine disorders affecting approximately one third of the working German
Brix Klaudia +2 more
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Chemistry ProceedingsMolecular modelling of the structure and evaluation of the chemical shifts of 1H and 13C nuclei were performed for the 4-[4-(2-aminoethoxy)benzyl]aniline, which is a structural analogue of thyronamines.
Dmytro Filimonov
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Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration [PDF]
Breast Cancer: Targets and Therapy, 2019 Eileen Tremmel,1 Simone Hofmann,1 Christina Kuhn,1 Helene Heidegger,1 Sabine Heublein,2 Kerstin Hermelink,1 Rachel Wuerstlein,1 Nadia Harbeck,1 Doris Mayr,3 Sven Mahner,1 Nina Ditsch,1 Udo Jeschke,1 Aurelia Vattai1 1Breast Center, Department of ...
Tremmel E +12 more
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Mini Review: Relational Stability in the Expression of Normality, Variation and Control of Thyroid Function [PDF]
Frontiers in Endocrinology, 2016 Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary TSH. In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital.
Rudolf Hoermann +3 more
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Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? [PDF]
Frontiers in Endocrinology, 2023 We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) in the adult brain.
Joseph V. Martin, Pradip K. Sarkar
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Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline [PDF]
AntioxidantsThe release of reactive oxygen species accompanying oxidative stress is one of the most significant damaging mechanisms during brain ischemia. Some aspects of the neuroprotective activity of the thyronamine T0AM synthetic analogue, 4-[4-(2-aminoethoxy ...
Dmitry A. Filimonov +7 more
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New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection [PDF]
Frontiers in Pharmacology, 2017 3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain.
Lorenza Bellusci +13 more
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Molecular Basis for Certain Neuroprotective Effects of Thyroid Hormone [PDF]
Frontiers in Molecular Neuroscience, 2011 The pathophysiology of brain damage that is common to ischemia-reperfusion inury and brain trauma includes disordered neuronal and glial cell energetics, intracellular acidosis, calcium toxicity, extracellular excitotoxic glutamate accumulation and ...
Paul eDavis +7 more
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Lessons from Randomised Clinical Trials for Triiodothyronine Treatment of Hypothyroidism: Have They Achieved Their Objectives? [PDF]
J Thyroid Res, 2018 Randomised controlled trials are deemed to be the strongest class of evidence in evidence‐based medicine. Failure of trials to prove superiority of T3/T4 combination therapy over standard LT4 monotherapy has greatly influenced guidelines, while not resolving the ongoing debate.
Hoermann R +3 more
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