Results 31 to 40 of about 244 (108)

Cardiac actions of thyroid hormone metabolites [PDF]

, 2017
Thyroid hormones (THs) have a major role in regulating cardiac function. Their classical mechanism of action is genomic. Recent findings have broadened our knowledge about the (patho)physiology of cardiac regulation by THs, to include non-genomic actions
Zucchi, Riccardo, Rutigliano, Grazia
core   +1 more source

Ligand Recognition and Function of TAARs

Sensory Neuroscience, Volume 1, Issue 2, September 2025.
The trace amine‐associated receptor (TAAR) family represents a highly conserved group of G protein‐coupled receptors (GPCRs) in vertebrates. TAARs specifically bind to different amine ligands and mediate a variety of physiological and behavioral processes.
Kang‐Ying Qian, Yue Hao, Zheng Wang, Qian Li   +3 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists [PDF]

, 2015
Trace amine associated receptor 1 (TAAR1) is a G protein coupled receptor (GPCR) expressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limited to, trace amines (TAs), amphetamine-like psychostimulants, and ...
Fossa P, Laurino A, Espinoza S, Rapposelli S, Chiellini G, Nesi G, Digiacomo M, Frascarelli S, Gainetdinov RR, Sabatini M, Macchia M, Cichero E, Zucchi R, Malvasi R, Raimondi L   +14 more
core   +2 more sources

Modified Chromenes as Precursors to TAAR Regulators [PDF]

, 2011
200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates.
Lehmann, Jonathan, Hart, Matthew
core  

An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine.

, 2010
Thryonamines are exciting new players at the crossroads of thyroidology and metabolism. Here we report the development of a method to measure 3 iodothyronamine (T1AM) and thyronamine (T0AM) in plasma and tissue samples.
Klieverik, L.P., Kalsbeek, A., P Ringeling, L P Klieverik, Endert, Erik, Fliers, Eric, M T Ackermans, E Fliers, Kalsbeek, Andries, A Kalsbeek, Endert, E., E Endert, Ringeling, P., Fliers, E., Ackermans, M.T., Ackermans, Mariette T., Klieverik, Lars P., Ringeling, Peter   +17 more
core   +1 more source

Trace amine receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families.
Maguire, Janet J., Parker, William A.E., Davenport, Anthony P., Bonner, Tom I., Foord, Stephen M.   +4 more
core   +1 more source

Effect of a synthetic analogue of thyronamine on the levels of molecular markers of focal brain damage in an experimental model

Анналы клинической и экспериментальной неврологии
Introduction. Therapeutic options for ischemic stroke (IS) are largely limited to reperfusion, underscoring the importance of exploring new approaches to neuroprotection and neurorepair.
Dmitry A. Filimonov, Nadezhda N. Trubnikova, Irina A. Kisilenko, Margarita A. Belotserkovskaya, Anzhelika A. Burtseva, Albina E. Glebova, Roman V. Ishchenko, Alexander B. Eresko, Elena V. Raksha, Dinara Sh. Diuba, Elena S. Berdnikovitch   +10 more
doaj   +1 more source

Cardiac effects of thyronamines

, 2010
3-Iodothyronamine (T(1)AM) is an endogenous compound derived from thyroid hormone through decarboxylation and deiodination, which interacts with a novel G protein-coupled receptor, known as trace amine-associated receptor 1 (TAAR1).
GHELARDONI, SANDRA, CHIELLINI, GRAZIA, ZUCCHI, RICCARDO   +2 more
core   +1 more source

Thyroid metabolism and supplementation: A review framed in sports environment

, 2022
Objectives: This paper aimed to consider those features that may suggest a link between thyroid hormones pharmacology and athletes' health based on current consumption trends in a population of athletes.
de la Torre, X., Martínez Brito, D., Botrè, Francesco, Xavier de la Torre, Romanelli, F., Botrè, F., Francesco Romanelli, Dayamin Martínez Brito, de la Torre, Xavier, Francesco Botrè, Martínez Brito, Dayamin, Romanelli, Francesco   +11 more
core   +1 more source

Exploring the Non-Transcriptional Activity of Thyroid Hormone Derivatives [PDF]

, 2008
This work is premised on the hypothesis that thyroid hormone may be a substrate for the aromatic L-amino acid decarboxylase (AADC) and that the resulting iodothyronamines would have significant structural and perhaps functional similarity with several ...
Snead, Aaron Nathan
core