Results 21 to 30 of about 244 (108)

Trace Amine-Associated Receptor Agonists:  Synthesis and Evaluation of Thyronamines and Related Analogues

, 2016
We have previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormone, potently activate an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale [Scanlan,
Motonori Miyakawa (2488492), David K. Grandy (2385319), Matthew E. Hart (2651641), Thomas S. Scanlan (71862), Katherine L. Suchland (327116), James R. Bunzow (2385322)   +5 more
core   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

British Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Maria P Abbracchio, Wayne Alexander, Khaled Al-hosaini, Magnus Bäck, Jean‐Martin Beaulieu, Kenneth E. Bernstein, Bernhard Bettler, Nigel JM Birdsall, Victoria Blaho, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Jerold Chun, Antonia Cianciulli, Lucie H Clapp, Réjean Couture, Zsolt Csaba, Gordon Dent, Khuraijam Dhanachandra Singh, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward Filardo, Tung M Fong, Marta Fumagalli, Raul R Gainetdinov, Marc de Gasparo, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie Hay, Akos Heinemann, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P Ijzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Paweł Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin C Michel, Laurence Miller, Vincenzo Mitolo, Bernard Mouillac, Philip M Murphy, Jean‐Louis Nahon, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O'Carroll, Stefan Offermanns, Maria A Panaro, Roger G Pertwee, Jean‐Philippe Pin, Eric Prossnitz, Rithwik Ramachandran, Rainer K Reinscheid, Philippe Rondard, G Enrico Rovati, Chiara Ruzza, Gareth Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Leigh A Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie Tan, Walter Thomas, Pieter BMWM Timmermans, Kalyan Tirupula, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean‐Pierre Vilardaga, Christopher S Walker, Donald T Ward, Hans‐Jürgen Wester, Gary B Willars, Tom Lloyd Williams, Trent M Woodruff, Chengcan Yao   +138 more
wiley   +1 more source

Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Recently, in vivo confocal microscopy is used to examine the human corneal nerve fibers morphology. Corneal nerve fiber architecture and its role are studied in healthy and pathological conditions. Corneal nerves of rats were studied by nonspecific acetylcholinesterase (NsAchE) staining.
Hiroshi Eguchi, Akio Hiura, Hiroshi Nakagawa, Shunji Kusaka, Yoshikazu Shimomura, Barbara K. Pierscionek   +5 more
wiley   +1 more source

The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration

Oxidative Medicine and Cellular Longevity, Volume 2013, Issue 1, 2013., 2013
Reactive oxygen species (ROS) are oxidizing agents amply implicated in tissue damage. ROS production is inevitably linked to ATP synthesis in most cells, and the rate of production is related to the rate of cell respiration. Multiple antioxidant mechanisms limit ROS dispersion and interaction with cell components, but, when the balance between ROS ...
I. Villanueva, C. Alva-Sánchez, J. Pacheco-Rosado, Sathyasaikumar V. Korrapati   +3 more
wiley   +1 more source

TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis

Journal of Thyroid Research, Volume 2012, Issue 1, 2012., 2012
This paper provides the reader with an overview of our current knowledge of hypothalamic‐pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical ...
Johannes W. Dietrich, Gabi Landgrafe, Elisavet H. Fotiadou, Rudolf Hoermann   +3 more
wiley   +1 more source

Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development

Journal of Thyroid Research, Volume 2011, Issue 1, 2011., 2011
Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3′,5‐triiodo‐L‐thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain.
Fabrice Chatonnet, Frédéric Picou, Teddy Fauquier, Frédéric Flamant, Juan Bernal   +4 more
wiley   +1 more source

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Maria Qatato, Joanna Szumska, Vladislav Skripnik, Eddy Rijntjes, Josef Köhrle, Klaudia Brix   +5 more
doaj   +1 more source

Central effects of thyronamines on glucose metabolism in rats.

, 2009
Thyronamines are naturally occurring, chemical relatives of thyroid hormone. Systemic administration of synthetic 3-iodothyronamine (T(1)AM) and - to a lesser extent - thyronamine (T(0)AM), leads to acute bradycardia, hypothermia, decreased metabolic ...
Kalsbeek, A., Klieverik, L.P., Scanlan, T.S., Scanlan, Thomas S., Fliers, Eric, Klieverik, L.P, Foppen, Ewout, Ackermans, Mariëtte T., Scanlan, T., Sauerwein, Hans P., Serlie, M.J., Grandy, D., Kalsbeek, Andries, Foppen, E., Fliers, E., Ackermans, M.T., Grandy, David K., Grandy, D.K., Klieverik, Lars P., Serlie, Mireille J., Sauerwein, H.P.   +20 more
core   +1 more source

Pharmacological and metabolic effects of thyronamines [PDF]

, 2013
Адрес за кореспонденция: Д-р Даниела Гавраилова, Факултет „Обществено здраве”, МУ, 1527 София, ул. „Бяло море” 8, тел.: 02 9432-219 ***** Address for correspondence: Daniela Gavrailova, MD, Faculty of Public Health, Medical University, 8 Byalo more st.,
Гавраилова/Gavrailova, Д./D.
core   +1 more source

Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

PLoS ONE, 2011
Trace amine-associated receptors (TAAR) are rhodopsin-like G-protein-coupled receptors (GPCR). TAAR are involved in modulation of neuronal, cardiac and vascular functions and they are potentially linked with neurological disorders like schizophrenia and ...
Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann   +8 more
doaj   +1 more source