IMPACT OF THYRONAMINE ANALOGUE ON LIPID PEROXIDATION IN THE BRAIN OF RATS
Клінічна та профілактична медицина, 2023 Introduction. Thyronamines belong to agonists of TAAR1 - trace amine receptors in the brain. The mechanism of activation of the processes of autophagy and neuroplasticity under the action of a synthetic analogue of thyronamines – 4-(4-(2-aminoethoxy ...
Hanna Fedorova +2 more
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Editorial: Nongenomic influences of thyroid hormones and their metabolites in adults: a tribute to Mary B. Dratman [PDF]
Frontiers in Endocrinology, 2023 Pradip K. Sarkar, Joseph V. Martin
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Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity [PDF]
Molecular and Cellular Endocrinology, 2011 Thyronamines T(0)AM and T(1)AM are naturally occurring decarboxylated thyroid hormone derivatives. Their in vivo administration induces effects opposite to those induced by thyroid hormone, including lowering of body temperature. Since the mitochondrial energy-transduction apparatus is known to be a potential target of thyroid hormone and its ...
Gaetana Napolitano +2 more
exaly +10 more sources
Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. [PDF]
Biomed Res Int, 2017 Recently, in vivo confocal microscopy is used to examine the human corneal nerve fibers morphology. Corneal nerve fiber architecture and its role are studied in healthy and pathological conditions. Corneal nerves of rats were studied by nonspecific acetylcholinesterase (NsAchE) staining.
Eguchi H +4 more
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A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes. [PDF]
PLoS ONE, 2017 Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH ...
Keith H Richards +5 more
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Анналы клинической и экспериментальной неврологииIntroduction. Therapeutic options for ischemic stroke (IS) are largely limited to reperfusion, underscoring the importance of exploring new approaches to neuroprotection and neurorepair.
Dmitry A. Filimonov +10 more
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Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study [PDF]
Molecules, 2021 Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by modulating energy metabolism and neurological functions in mice.
Nicoletta di Leo +11 more
openaire +5 more sources
In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice. [PDF]
Eur Thyroid J, 2018 Abstract Objectives: Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormones (THs). Of all possible thyronamine variants, only 3-iodothyronamine (3-T<sub>1</sub>AM) and iodine-free thyronamine (T<sub>0</sub>AM) have been detected in vivo.
Harder L +7 more
europepmc +4 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source