Results 31 to 40 of about 233 (110)

Molecular Basis for Certain Neuroprotective Effects of Thyroid Hormone

Frontiers in Molecular Neuroscience, 2011
The pathophysiology of brain damage that is common to ischemia-reperfusion inury and brain trauma includes disordered neuronal and glial cell energetics, intracellular acidosis, calcium toxicity, extracellular excitotoxic glutamate accumulation and ...
Paul eDavis, Paul eDavis, Hung-Yun eLin, Faith B Davis, Mary eLuidens, Shaker eMousa, James eCao, Min eZhou   +7 more
doaj   +1 more source

The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration

Oxidative Medicine and Cellular Longevity, Volume 2013, Issue 1, 2013., 2013
Reactive oxygen species (ROS) are oxidizing agents amply implicated in tissue damage. ROS production is inevitably linked to ATP synthesis in most cells, and the rate of production is related to the rate of cell respiration. Multiple antioxidant mechanisms limit ROS dispersion and interaction with cell components, but, when the balance between ROS ...
I. Villanueva, C. Alva-Sánchez, J. Pacheco-Rosado, Sathyasaikumar V. Korrapati   +3 more
wiley   +1 more source

TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis

Journal of Thyroid Research, Volume 2012, Issue 1, 2012., 2012
This paper provides the reader with an overview of our current knowledge of hypothalamic‐pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical ...
Johannes W. Dietrich, Gabi Landgrafe, Elisavet H. Fotiadou, Rudolf Hoermann   +3 more
wiley   +1 more source

Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development

Journal of Thyroid Research, Volume 2011, Issue 1, 2011., 2011
Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3′,5‐triiodo‐L‐thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain.
Fabrice Chatonnet, Frédéric Picou, Teddy Fauquier, Frédéric Flamant, Juan Bernal   +4 more
wiley   +1 more source

Proof of Concept of the Electrochemical Sensing of 3‐Iodothyronamine (T₁AM) and Thyronamine (T₀AM) [PDF]

ChemElectroChem, 2014
AbstractRecent studies have shown that, besides the well‐recognized T3 and T4 hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3‐iodothyronamine (T1AM) and thyronamine (T0AM). One of the reasons for the lack of studies showing their precise importance is the absence of analytical ...
Gonçalves, Luís M., Moreira, Manuela M., Azevedo, Carla F., Valente, Inês M., Sousa, João Carlos, Scanlan, Thomas S., Compton, Richard G., Rodrigues, José A.   +7 more
openaire   +4 more sources

Electrochemical sensing of the thyroid hormone thyronamine (T0AM) via molecular imprinted polymers (MIPs) [PDF]

Talanta, 2019
Recent studies have shown that besides the well-known T3 (triiodothyronine) and T4 (thyroxine) there might be other important thyroid hormones, in particular T0AM (thyronamine) and T1AM (3-iodothyronamine). The absence of a large number of studies showing their precise importance might be explained by the limited number of analytical methodologies ...
Pacheco, João, Rebelo, Patrícia, Cagide, Fernando, Gonçalves, Luís Moreira, Borges, Fernanda, Rodrigues, José António, Delerue-Matos, Cristina   +6 more
openaire   +3 more sources

Ligand Recognition and Function of TAARs

Sensory Neuroscience, Volume 1, Issue 2, September 2025.
The trace amine‐associated receptor (TAAR) family represents a highly conserved group of G protein‐coupled receptors (GPCRs) in vertebrates. TAARs specifically bind to different amine ligands and mediate a variety of physiological and behavioral processes.
Kang‐Ying Qian, Yue Hao, Zheng Wang, Qian Li   +3 more
wiley   +1 more source

Thyronamines and Derivatives: Physiological Relevance, Pharmacological Actions, and Future Research Directions

Thyroid®, 2016
Thyronamines (3-T 1 AM, T 0 AM) are endogenous compounds probably derived from L-thyroxine or its intermediate metabolites. Combined activities of intestinal deiodinases and ornithine decarboxylase generate 3-T 1 ...
Hoefig, Carolin Stephanie, ZUCCHI, RICCARDO, Köhrle, Josef   +2 more
openaire   +3 more sources

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists [PDF]

Journal of Medicinal Chemistry, 2015
Trace amine associated receptor 1 (TAAR1) is a G protein coupled receptor (GPCR) expressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limited to, trace amines (TAs), amphetamine-like psychostimulants, and endogenous thyronamines such as thyronamine (T0AM) and 3-iodothyronamine (T1AM). Such polypharmacology
CHIELLINI, GRAZIA, NESI, GIULIA, DIGIACOMO, MARIA, Malvasi, Rossella, Espinoza, Stefano, SABATINI, MARTINA, FRASCARELLI, SABINA, Laurino, Annunziatina, Cichero, Elena, MACCHIA, MARCO, Gainetdinov, Raul R., Fossa, Paola, Raimondi, Laura, ZUCCHI, RICCARDO, RAPPOSELLI, SIMONA   +14 more
openaire   +7 more sources

Adipose Tissue Remodeling in Obesity: An Overview of the Actions of Thyroid Hormones and Their Derivatives. [PDF]

Pharmaceuticals (Basel), 2023
Petito G, Cioffi F, Magnacca N, de Lange P, Senese R, Lanni A.   +5 more
europepmc   +1 more source