Thyroxine metabolite-derived 3-iodothyronamine (T1AM) and synthetic analogs as efficient suppressors of transthyretin amyloidosis [PDF]
Computational and Structural Biotechnology Journal, 2023 Aggregation and fibrillization of transthyretin (TTR) is a fatal pathogenic process that can cause cardiomyopathic and polyneuropathic diseases in humans.
Gabriella Ortore +2 more
exaly +10 more sources
Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1) [PDF]
International Journal of Molecular Sciences, 2022 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1) are thyroid-hormone-related compounds endowed with pharmacological activity through mechanisms that remain elusive. Some evidence suggests that they may have redox features. We assessed the chemical activity of T1AM and TA1 at pro-oxidant conditions.
Maura Lodovici +2 more
exaly +10 more sources
Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes [PDF]
Scientific Reports, 2022 There is growing interest in 3-iodothyronamine (T1AM), an active thyroid hormone metabolite, that induces negative inotropic and chronotropic actions in the heart and exerts systemic hypothermic action.
Haruka Kimura +2 more
exaly +5 more sources
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors [PDF]
European Journal of Pharmacology, 2016 3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic transmission.
Annunziatina Laurino +2 more
exaly +7 more sources
T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line. [PDF]
Int J Mol Sci, 2023 Microglial dysfunction is one of the hallmarks and leading causes of common neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD) and Parkinson’s disease (PD). All these pathologies are characterized by aberrant aggregation of disease-causing proteins in the brain, which can directly activate microglia, trigger microglia-mediated ...
Polini B +7 more
europepmc +5 more sources
Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6 [PDF]
Molecules, 2020 3-iodothyronamine (T1AM) and the recently developed analog SG-2 are rapidly emerging as promising multi-target neuroprotective ligands able to reprogram lipid metabolism and to produce memory enhancement in mice.
Francesco Fornai +2 more
exaly +6 more sources
Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data [PDF]
Metabolites, 2022 We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration.
Nour Diab +5 more
doaj +2 more sources
T1AM Attenuates the Hypoxia/Reoxygenation-Induced Necroptosis of H9C2 Cardiomyocytes via RIPK1/RIPK3 Pathway. [PDF]
Biomed Res Int, 2022 Purpose. To investigate the detailed mechanism of 3‐iodothyronamine (T1AM) in cell apoptosis and programmed necrosis of hypoxia/reoxygenation‐ (H/R‐) induced H9C2 injury. Materials and Methods. Cardiomyocyte H9C2 cells were cultured in vitro for the establishment of cardiomyocyte H/R models.
Wei B +11 more
europepmc +4 more sources
Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study [PDF]
Molecules, 2021 Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by ...
Nicoletta di Leo +11 more
doaj +2 more sources
3-Iodothyronamine Affects Thermogenic Substrates’ Mobilization in Brown Adipocytes [PDF]
Biology, 2020 We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were exposed to an adipogenic medium containing insulin in the absence (M) or ...
Manuela Gencarelli +6 more
doaj +2 more sources