Results 11 to 20 of about 628 (165)

Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway [PDF]

International Journal of Molecular Sciences, 2019
3-Iodothyronamine (T1AM) and its synthetic analog SG-2 are rapidly emerging as promising drivers of cellular metabolic reprogramming. Our recent research indicates that in obese mice a sub-chronic low dose T1AM treatment increased lipolysis, associated with significant weight loss independent of food consumption. The specific cellular mechanism of T1AM’
Grazia Chiellini, Fariba M Assadi-Porter, Grazia Chiellini   +2 more
exaly   +6 more sources

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection [PDF]

Frontiers in Pharmacology, 2017
3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain.
Lorenza Bellusci, Annunziatina Laurino, Martina Sabatini, Simona Sestito, Paola Lenzi, Laura Raimondi, Simona Rapposelli, Francesca Biagioni, Francesco Fornai, Francesco Fornai, Alessandra Salvetti, Leonardo Rossi, Riccardo Zucchi, Grazia Chiellini   +13 more
doaj   +8 more sources

Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4. [PDF]

Endocrinology, 2012
Abstract 3-Iodothyronamine (T1AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T1AM is an extrathyroidal metabolite of T4. This study uses an isotope-labeled T4 [heavy-T4 (H-T4)] that can be distinguished from endogenous T4 by mass spectrometry ...
Riccardo Zucchi, Alessandro Saba, Thomas S Scanlan   +2 more
exaly   +4 more sources

T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex [PDF]

Neurobiology of Disease, 2021
Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke.
Francesca Tozzi, Grazia Rutigliano, Marco Borsò, Chiara Falcicchia, Riccardo Zucchi, Nicola Origlia   +5 more
doaj   +2 more sources

3-iodothyronamine (T1AM) effects on glutamatergic postsynaptic signaling pathway [PDF]

, 2022
Thyroid hormones (TH), namely thyroxine (T4) and 3,5,3’-triiodothyronine (T3), are crucial regulators of multiple growth processes and control systems of energy metabolism. T4 and T3 undergo a complex metabolism in vivo, by several enzymes encompassing deiodinases, amine transferases, amine oxidases, decarboxylases and several classes of conjugating ...
Bandini Lavinia
openaire   +3 more sources

Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study [PDF]

Endocrine Abstracts, 2016
Background: Critical illness is hallmarked by low circulating thyroxine (T4) and triiodothyronine (T3) concentrations, in the presence of elevated reverse T3 (rT3) and low-normal thyrotropin (TSH), referred to as nonthyroidal illness (NTI).
Langouche, Lies, Lehmphul, Ina, Vander Perre, Sarah, Köhrle, Josef, Van den Berghe, Greet   +4 more
openaire   +4 more sources

Pharmacological effects of 3‐iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold [PDF]

British Journal of Pharmacology, 2012
Background and Purpose3‐Iodothyronamine (T1AM), an endogenous derivative of thyroid hormones, is regarded as a rapid modulator of behaviour and metabolism. To determine whether brain thyroid hormone levels contribute to these effects, we investigated the effect of central administration of T1AM on learning and pain threshold of mice either untreated or
Maria Elena Manni, DE SIENA, GAETANO, Alessandro Saba, Maja Marchini, LANDUCCI, ELISA, GERACE, ELISABETTA, Marina Zazzeri, Claudia Musilli, PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO, MATUCCI, ROSANNA, Riccardo Zucchi, RAIMONDI, LAURA   +11 more
openaire   +5 more sources

An injectable refrigerated hydrogel for inducing local hypothermia and neuroprotection against traumatic brain injury in mice [PDF]

Journal of Nanobiotechnology
Background Hypothermia is a promising therapy for traumatic brain injury (TBI) in the clinic. However, the neuroprotective outcomes of hypothermia-treated TBI patients in clinical studies are inconsistent due to several severe side effects.
Yuhan Han, Zhengzhong Han, Xuyang Huang, Shanshan Li, Guoliang Jin, Junfeng Feng, Decheng Wu, Hongmei Liu   +7 more
doaj   +2 more sources

Proof of Concept of the Electrochemical Sensing of 3‐Iodothyronamine (T₁AM) and Thyronamine (T₀AM) [PDF]

ChemElectroChem, 2014
AbstractRecent studies have shown that, besides the well‐recognized T3 and T4 hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3‐iodothyronamine (T1AM) and thyronamine (T0AM). One of the reasons for the lack of studies showing their precise importance is the absence of analytical ...
Gonçalves, Luís M., Moreira, Manuela M., Azevedo, Carla F., Valente, Inês M., Sousa, João Carlos, Scanlan, Thomas S., Compton, Richard G., Rodrigues, José A.   +7 more
openaire   +6 more sources

Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM). [PDF]

Biomed Res Int, 2020
Background. The thyroid hormone metabolite 3‐iodothyronamine (3‐T1AM) is rapidly emerging as a promising compound in decreasing the heart rate and lowering the cardiac output. The aim of our study was to fully understand the molecular mechanism of 3‐T1AM on cardiomyocytes and its potential targets in cardiovascular diseases. Materials and Methods.
Haiyan Z, Bailong H, Bei Z, Yiming W, Xingde L.   +4 more
europepmc   +4 more sources