Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders [PDF]
Frontiers in Medicine, 2020 Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growth, development, and metabolism. A lack of thyroid hormones is not compatible with normal health.
Federica Saponaro +5 more
doaj +5 more sources
Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? [PDF]
Frontiers in Endocrinology, 2023 We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) in the adult brain.
Joseph V. Martin, Pradip K. Sarkar
doaj +3 more sources
Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. [PDF]
J Vet Med, 2013 The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines ...
Jovanović IB +5 more
europepmc +4 more sources
A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes. [PDF]
PLoS ONE, 2017 Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH ...
Keith H Richards +5 more
doaj +3 more sources
Genetically encoding thyronine for fluorescent detection of peroxynitrite [PDF]
Bioorganic and Medicinal Chemistry, 2020 Peroxynitrite is a highly reactive oxidant effecting cell signaling and cell death. Here we report a fluorescent protein probe to selectively detect peroxynitrite. A novel unnatural amino acid, thyronine (Thy), was genetically encoded in E. coli and mammalian cells by evolving an orthogonal tRNAPyl/ThyRS pair.
Bing Yang, Lei Wang, Bingchen Yu
exaly +7 more sources
Naturally Occurring Mutations in the Thyroglobulin Gene [PDF]
Thyroid, 2005 Thyroglobulin (Tg) is a large glycoprotein dimer secreted into the follicular lumen. It serves as the matrix for the synthesis of thyroxine (T4) and triiodothyronine (T3), and the storage of thyroid hormone and iodide.
Jussara Vono-Toniolo +4 more
semanticscholar +2 more sources
THF EFFECT OF VITAMIN E ON THYROID ACTIVITY OF CHICKENS AS ASSESSED By 125, [PDF]
Assiut Veterinary Medical Journal, 1975 SUMMARY Two groups of growing chickens "Dokki 4" were reared on a balanced diet up to 10 weeks of age. On the 8th. week, the first group was injected with olive oil while the second group was in jected with vitamin E.
M.S. Abdo, A.A. Farahat, M. EI-S.Attia
doaj +1 more source
Annals of Hepatology, 2017 Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in industrialized countries and is associated with increased risk of cardiovascular, hepatic and metabolic diseases.
Elena Grasselli +5 more
doaj +1 more source
ELECTRON MICROSCOPIC AUTORADIOGRAPHY
Journal of Cell Biology, 1964 Iodide is concentrated from the blood by the thyroid gland; after oxidation it is incorporated in tyrosyl residues of the thyroglobulin molecule. Thus the halogen is stored as a component of thyroglobulin in the colloid of the thyroid follicle. Secretion
H. Sheldon, J. Mckenzie, D. Van Nimwegan
semanticscholar +1 more source
T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line. [PDF]
Int J Mol Sci, 2023 Polini B +7 more
europepmc +1 more source