Results 21 to 30 of about 628 (165)

Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression [PDF]

International Journal of Molecular Sciences, 2018
Obesity is a complex disease associated with environmental and genetic factors. 3-Iodothyronamine (T1AM) has revealed great potential as an effective weight loss drug. We used metabolomics and associated transcriptional gene and protein expression analysis to investigate the tissue specific metabolic reprogramming effects of subchronic T1AM treatment ...
Assadi-Porter, Fariba M., Reiland, Hannah, Sabatini, Martina, Lorenzini, Leonardo, Carnicelli, Vittoria, Rogowski, Micheal, Selen Alpergin, Ebru S., Tonelli, Marco, Ghelardoni, Sandra, Saba, Alessandro, Zucchi, Riccardo, Chiellini, Grazia   +11 more
openaire   +5 more sources

Effect of Combined Levothyroxine (L-T₄) and 3-Iodothyronamine (T₁AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse Model of Hypothyroidism. [PDF]

Int J Mol Sci, 2023
Mood alterations, anxiety, and cognitive impairments associated with adult-onset hypothyroidism often persist despite replacement treatment. In rodent models of hypothyroidism, replacement does not bring 3-iodothyronamine (T1AM) brain levels back to ...
Rutigliano G, Bertolini A, Grittani N, Frascarelli S, Carnicelli V, Ippolito C, Moscato S, Mattii L, Kusmic C, Saba A, Origlia N, Zucchi R.   +11 more
europepmc   +2 more sources

Exogenous 3-Iodothyronamine (T₁AM) Can Affect Phosphorylation of Proteins Involved on Signal Transduction Pathways in In Vitro Models of Brain Cell Lines, but These Effects Are Not Strengthened by Its Catabolite, 3-Iodothyroacetic Acid (TA₁). [PDF]

Life (Basel), 2022
T1AM, a derivative of thyroid hormones, and its major catabolite, TA1, produce effects on memory acquisition in rodents. In the present study, we compared the effects of exogenous T1AM and TA1 on protein belonging to signal transduction pathways ...
Bandini L, Sacripanti G, Borsò M, Tartaria M, Fogliaro MP, Giannini G, Carnicelli V, Figuccia ME, Verlotta S, De Antoni F, Zucchi R, Ghelardoni S.   +11 more
europepmc   +2 more sources

Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases

Frontiers in Endocrinology, 2018
3-Iodothyronamine (T1AM) is the last iodinated thyronamine generated from thyroid hormone alternative metabolism found circulating in rodents and in humans. So far, the physiopathological meaning of T1AM tissue levels is unknown. Much is instead known on
Annunziatina Laurino, Elisa Landucci, Laura Raimondi   +2 more
doaj   +1 more source

3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?

Frontiers in Endocrinology, 2017
The decarboxylated and deiodinated thyroid hormone (TH) derivative, 3-iodothyronamine (3-T1AM), is suggested to be involved in energy metabolism and thermoregulation.
Noushafarin Khajavi, Stefan Mergler, Heike Biebermann   +2 more
doaj   +1 more source

3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines

Frontiers in Endocrinology, 2018
3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to ...
Julia Bräunig, Julia Bräunig, Stefan Mergler, Sabine Jyrch, Sabine Jyrch, Carolin S. Hoefig, Carolin S. Hoefig, Mark Rosowski, Jens Mittag, Jens Mittag, Heike Biebermann, Heike Biebermann, Noushafarin Khajavi, Noushafarin Khajavi   +13 more
doaj   +1 more source

Update on 3-iodothyronamine and its neurological and metabolic actions

Frontiers in Physiology, 2014
3-iodothyronamine (T1AM) is an endogenous amine, that has been detected many rodent tissues, and in human blood. It has been hypothesized to derive from thyroid hormone metabolism, but this hypothesis still requires validation.
Riccardo eZucchi, Alice eAccorroni, Grazia eChiellini   +2 more
doaj   +1 more source

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Frontiers in Pharmacology, 2018
Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig, Juliane Dinter, Carolin S. Höfig, Sarah Paisdzior, Michal Szczepek, Patrick Scheerer, Mark Rosowski, Jens Mittag, Gunnar Kleinau, Gunnar Kleinau, Heike Biebermann   +10 more
doaj   +1 more source

3-Iodothyronamine (T1AM): A New Player on the Thyroid Endocrine Team? [PDF]

Endocrinology, 2008
3-Iodothyronamine (T1AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T1AM has a carbon skeleton identical to that of T4 and contains a single carbon-iodine bond. Theoretically, T1AM could be produced from T4 by enzymatic decarboxylation and deiodination.
openaire   +2 more sources

Modulation of gene expression by 3-iodothyronamine: genetic evidence for a lipolytic pattern.

PLoS ONE, 2014
3-Iodothyronamine (T1AM) is an endogenous biogenic amine, structurally related to thyroid hormone, which is regarded as a novel chemical messenger. The molecular mechanisms underlying T1AM effects are not known, but it is possible to envisage changes in ...
Veronica Mariotti, Erika Melissari, Caterina Iofrida, Marco Righi, Manuela Di Russo, Riccardo Donzelli, Alessandro Saba, Sabina Frascarelli, Grazia Chiellini, Riccardo Zucchi, Silvia Pellegrini   +10 more
doaj   +1 more source