Results 31 to 40 of about 628 (165)
Frontiers in Pharmacology, 2018 The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized.
Xiaoqun Zhang +11 more
doaj +1 more source
Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
PLoS ONE, 2015 ObjectiveApplication of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still
Juliane Dinter +12 more
doaj +1 more source
A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes. [PDF]
PLoS ONE, 2017 Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH ...
Keith H Richards +5 more
doaj +1 more source
Torpor: The Rise and Fall of 3-Monoiodothyronamine from Brain to Gut—From Gut to Brain?
Frontiers in Endocrinology, 2017 3-Monoiodothyronamine (T1AM), first isolated from rat brain, is reported to be an endogenous, rapidly acting metabolite of thyroxine. One of its numerous effects is the induction of a “torpor-like” state in experimental animals.
Hartmut H. Glossmann, Oliver M. D. Lutz
doaj +1 more source
3-Iodothyronamine (T1AM) Reduces Inflammatory Response in Human Microglial HMC3 Cell Line
, 2023 Microglial dysfunction is one of the hallmarks and leading causes of common neurodegenerative diseases (NDD), including Alzheimer’s disease (AD) and Parkinson’s disease (PD). All these pathologies are characterized by aberrant aggregation of disease-causing proteins in the brain, which can directly activate microglia, trigger microglia-mediated ...
Beatrice Polini +7 more
openaire +1 more source
The Possible Role of 3-lodothyronamine in Browning of Inguinal White Adipose Tissue in Mice
Endocrinology Research and Practice, 2017 Purpose: In this study, we have investigated whether administration of a chronic low dose of 3-iodothyronamine (T1AM) could regulate the concentration of uncoupling protein 1 (UCP1) in mice inguinal white adipose tissue (IWAT).
Neda ESKANDARZADE +3 more
doaj +1 more source
Uptake of 3‐iodothyronamine hormone analogs inhibits the growth and viability of cancer cells
FEBS Open Bio, 2017 3‐Iodothyronamine (T1AM) is a structural analog of thyroid hormone that has been demonstrated to have potent affects on numerous physiological systems.
Michael Rogowski +3 more
doaj +1 more source
Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Similarities and Differences in the Peripheral Actions of Thyroid Hormones and Their Metabolites
Frontiers in Endocrinology, 2018 Thyroxine (T4) and 3,5,3'-triiodothyronine (T3) are secreted by the thyroid gland, while T3 is also generated from the peripheral metabolism of T4 by iodothyronine deiodinases types I and II.
Ruy A. Louzada, Denise P. Carvalho
doaj +1 more source
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, Volume 37, Issue 3, Page 365-374, June 2026.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source