The thyroid hormone derivative 3‐iodothyronamine increases food intake in rodents
Diabetes, Obesity and Metabolism, 2009 Background: The thyroid hormone derivative 3‐iodothyronamine (T 1 AM), an endogenous biogenic amine, is a potent agonist of the G protein–coupled trace amine‐associated receptor 1 (TAAR1).
Dhillo, W. S. +12 more
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SYNTHETIC ANALOGUES OF 3-IODOTHYRONAMINE (T1AM) AND USES THEREOF
, 2015 The present invention generally refers to synthetic analogues of thyroid hormones. More specifically, the invention relates to synthetic analogues of 3-iodothyronamine.
CHIELLINI GRAZIA +2 more
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Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression [PDF]
International Journal of Molecular Sciences, 2018 Grazia Chiellini +2 more
exaly +2 more sources
Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients
Frontiers in Endocrinology, 2021 Thyroxine and triiodothyronine (T3) are classical thyroid hormones and with relatively well-understood actions. In contrast, the physiological role of thyroid hormone metabolites, also circulating in the blood, is less well characterized. These molecules,
Eleonore Fröhlich +2 more
doaj +1 more source
Cardiac effects of 3‐iodothyronamine: a new aminergic system modulating cardiac function
The FASEB Journal, 2007 ABSTRACT 3‐iodothyronamine T 1 AM is a novel endogenous thyroid hormone derivative that activates the G protein‐coupled receptor known as trace anime‐associated receptor 1 (TAAR1). In the isolated working rat heart and in rat cardiomyocytes, T 1
CHIELLINI, GRAZIA +11 more
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Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold [PDF]
British Journal of Pharmacology, 2013 Elisabetta Gerace +2 more
exaly +2 more sources
Validation of a liquid chromatography–tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum [PDF]
Journal of Chromatography A, 2008 DeBarber AE +4 more
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Metabolites, 2022 We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration.
Nour Diab +5 more
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Nutritional and metabolic signalling through GPCRs
FEBS Letters, Volume 596, Issue 18, Page 2364-2381, September 2022., 2022 G‐protein‐coupled receptors can sense a plethora of nutrient‐derived or intermediary metabolism‐derived molecules, including succinate, lactate, β‐hydroxybutyrate, 3‐hydroxyoctanoic acid, free fatty acids and amino acids. Metabolite‐sensing GPCRs activate specific intracellular signalling cascades, ultimately affecting different processes in cancer ...
Elisa Pardella +3 more
wiley +1 more source