Results 51 to 60 of about 18,306,088 (139)
3-iodothyronamine as a potential anti-tumor compound
, 2014 Objectives: 3-iodothyronamine (T1AM) is an endogenous messenger chemically related to thyroid hormone, which produces significant effects on energy metabolism and modulates mammalian sirtuin expression. In particular, subchronic T1AM administration was reported to increase the expression of mammalian sirtuin 6 (SIRT6), which has a pro-apoptotic role ...
GHELARDONI, SANDRA +6 more
openaire +2 more sources
The cation channel TRPM8 influences the differentiation and function of human monocytes
Journal of Leukocyte Biology, Volume 112, Issue 3, Page 365-381, September 2022., 2022 Graphical Abstract TRPM8 in human monocytes promotes aspects of their differentiation to macrophages and acts at a critical early time point to limit inflammatory potential. Abstract Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment.
Eve Hornsby +8 more
wiley +1 more source
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Purpose. To investigate the detailed mechanism of 3‐iodothyronamine (T1AM) in cell apoptosis and programmed necrosis of hypoxia/reoxygenation‐ (H/R‐) induced H9C2 injury. Materials and Methods. Cardiomyocyte H9C2 cells were cultured in vitro for the establishment of cardiomyocyte H/R models.
Bo Wei +12 more
wiley +1 more source
Synthesis and Applications of Organic Selenols
Advanced Synthesis &Catalysis, Volume 363, Issue 24, Page 5360-5385, December 21, 2021., 2021 Abstract The synthesis and the study of organoselenium compounds have received much attention over the past decades. Selenium‐containing organic molecules are widely used in organic synthesis, materials science, and medicinal chemistry. Selenium – and more specifically the amino acid selenocysteine, bearing a selenol (SeH) moiety – is present in at ...
Damiano Tanini, Antonella Capperucci
wiley +1 more source
Identification and characterization of 3-iodothyronamine intracellular transport. [PDF]
Endocrinology, 2009 3-Iodothyronamine (T(1)AM) is a naturally occurring thyroid hormone metabolite with distinct biological effects that are opposite those of thyroid hormone. The known molecular targets of T(1)AM include both plasma membrane and intracellular proteins, suggesting that intracellular transport of T(1)AM may be an important component of its action, although
Ianculescu AG, Giacomini KM, Scanlan TS.
europepmc +3 more sources
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source
Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography–tandem mass spectrometry [PDF]
Journal of Chromatography A, 2012 Thomas S Scanlan
exaly +2 more sources
Pediatric Allergy and Immunology, Volume 32, Issue 6, Page 1296-1306, August 2021., 2021 Abstract Background Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to under‐diagnosis. MicroRNAs (miRNA) regulate physiologic and pathologic processes, and they have been postulated as promising diagnostic markers.
Emilio Nuñez‐Borque +15 more
wiley +1 more source
T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Neurobiology of Disease, 2021 Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke.
Francesca Tozzi +5 more
doaj +1 more source
Effect of 3-iodothyronamine on myocardial calcium homeostasis
, 2009 Objective: 3-iodothyronamine (T1AM) derives from thyroid hormone through decarboxylation anddeiodination, and binds to plasma membrane receptors known as trace amine-associated receptors. Since we have previously observed that T1AM produces a negative inotropic effect in rat heart (IC50close to 20 microM), in this work we determined the effect of T1AM ...
GHELARDONI, SANDRA +7 more
openaire +2 more sources