Results 61 to 70 of about 18,306,088 (139)
Up-take of thyronines and 3-iodothyronamine in liver cells
, 2012 Objectives: 3,5-diiodothyronine (T2) and 3-iodothyronamine (T1AM) are thyroid hormone derivatives which have been shown to produce significant biological effects. Some of these effects appear to involve the interaction with specific intracellular targets. In the present work we investigated whether T2 and T1AM are taken up by hepatocytes.
GHELARDONI, SANDRA +5 more
openaire +2 more sources
Mitochondrial F0F1-ATP synthase is a molecular target of 3-iodothyronamine, an endogenous metabolite of thyroid hormone [PDF]
British Journal of Pharmacology, 2012 Federico Fogolari, I Mavelli
exaly +2 more sources
, 2023 3-iodothyronamine (3-T1AM) has been suggested as a novel chemical messenger and potent trace amine-associated receptor 1 ligand in the CNS that occurs naturally as endogenous metabolite of the thyroid hormones.
Miller, M. +7 more
core +1 more source
The Possible Role of 3-lodothyronamine in Browning of Inguinal White Adipose Tissue in Mice
Endocrinology Research and Practice, 2017 Purpose: In this study, we have investigated whether administration of a chronic low dose of 3-iodothyronamine (T1AM) could regulate the concentration of uncoupling protein 1 (UCP1) in mice inguinal white adipose tissue (IWAT).
Neda ESKANDARZADE +3 more
doaj +1 more source
Modulation of cardiac calcium homeostasis by 3-iodothyronamine
, 2009 3-iodothyronamine (T1AM) is a thyroid hormone derivative which binds to a new class of plasma membrane receptors known as trace amine-associated receptors. We have shown that in isolated rat hearts and in adult rat cardiomyocytes T1AM produces a negative inotropic effect, with IC50 on the order of 20 microM.
CHIELLINI, GRAZIA +7 more
openaire +2 more sources
Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study
Molecules, 2021 Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by ...
Nicoletta di Leo +11 more
doaj +1 more source
, 2021 The 3-iodothyronamine (T1AM) and 3-iodothryoacetic acid (TA1), are endogenous occurring compounds structurally related with thyroid hormones (THs, the pro-hormone T4 and the active hormone T3) initially proposed as possible mediators of the rapid effects
Laurino, A. +2 more
core +1 more source
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages
Endocrine Connections, 2018 Objectives: l-dopa decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine, which binds to the D2-dopamine receptor (D2R), plays an important role in the maintenance of pregnancy.
Michael J Gratz +10 more
doaj +1 more source
Frontiers in Endocrinology, 2023 A comprehensive review was conducted to compile the contributions of Mary B. Dratman and studies by other researchers in the field of nongenomic actions of thyroid hormones in adult mammalian brain.
Nilkanta Chakrabarti +4 more
doaj +1 more source
Biosynthesis of 3-Iodothyronamine From T4 in Murine Intestinal Tissue [PDF]
Endocrinology, 2015 The endogenous metabolite 3-iodothyronamine (3-T1AM) induces strong hypothermia and bradycardia at pharmacological doses. Although its biosynthesis from thyroid hormone precursors appears likely, the sequence and sites of reactions are still controversial: studies in T4-substituted thyroid cancer patients lacking functional thyroid tissue suggested ...
Carolin S, Hoefig +7 more
openaire +2 more sources