Results 71 to 80 of about 18,306,088 (139)

A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes. [PDF]

open access: yesPLoS ONE, 2017
Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH ...
Keith H Richards   +5 more
doaj   +1 more source

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

open access: yesFrontiers in Pharmacology, 2019
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions.
Grazia Rutigliano   +13 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander   +138 more
wiley   +1 more source

ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation. [PDF]

open access: yesJ Biol Chem, 2012
3-Iodothyronamine (T(1)AM) is a biogenic amine derivative of thyroid hormone present in tissue and blood of vertebrates. Approximately 99% of the circulating thyroid hormones are bound to plasma proteins, including three major thyroid hormone-binding proteins, and the question arises as to whether circulating T(1)AM is also bound to serum factors.
Roy G, Placzek E, Scanlan TS.
europepmc   +4 more sources

Revisiting Thyroid Hormones in Schizophrenia

open access: yesJournal of Thyroid Research, Volume 2012, Issue 1, 2012., 2012
Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment.
Nadine Correia Santos   +9 more
wiley   +1 more source

TRPM8 Regulates Mitochondrial Ca2+‐Dynamics, Temperature and Endoplasmic Reticulum‐Mitochondrial Contact Points in T Cell

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT TRPM8 is a cold temperature‐sensitive and non‐selective Ca2+‐channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub‐cellular compartments.
Tusar Kanta Acharya   +5 more
wiley   +1 more source

The Central Effects of Thyroid Hormones on Appetite

open access: yesJournal of Thyroid Research, Volume 2011, Issue 1, 2011., 2011
Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid the development of new treatments. The hypothalamic‐pituitary‐thyroid (HPT) axis has well‐known effects on energy expenditure, but its role in the regulation of food intake is ...
Anjali Amin   +3 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +206 more
wiley   +1 more source

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 135, Issue 6, Page 720-742, December 2024.
Abstract Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still unidentified proton organic cation (H+/OC) antiporter is found in several tissues, including endothelial cells of the BBB.
Cauzar Ali Khan   +3 more
wiley   +1 more source

Modified Chromenes as Precursors to TAAR Regulators [PDF]

open access: yes, 2011
200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates.
Lehmann, Jonathan, Hart, Matthew
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