Results 91 to 100 of about 18,306,088 (139)

Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment

Frontiers in Psychiatry
For over seven decades, dopamine receptor 2 (D2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective for treating hyperdopaminergic symptoms, it is often ineffective for treating negative and ...
Britto Shajan, Tarun Bastiampillai, Tarun Bastiampillai, Shane D. Hellyer, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair   +7 more
doaj   +1 more source

An injectable refrigerated hydrogel for inducing local hypothermia and neuroprotection against traumatic brain injury in mice

Journal of Nanobiotechnology
Background Hypothermia is a promising therapy for traumatic brain injury (TBI) in the clinic. However, the neuroprotective outcomes of hypothermia-treated TBI patients in clinical studies are inconsistent due to several severe side effects.
Yuhan Han, Zhengzhong Han, Xuyang Huang, Shanshan Li, Guoliang Jin, Junfeng Feng, Decheng Wu, Hongmei Liu   +7 more
doaj   +1 more source

Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway. [PDF]

Med Sci Monit, 2020
Zhou H, Hu B, Liu X.
europepmc   +1 more source

Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

, 2012
3-Iodothyronamine (T1AM) is a novel chemical messenger, structurally related to thyroid hormone, able to interact with G protein-coupled receptors known as trace amine-associated receptors (TAARs). Little is known about the physiological role of T1AM. In
GHELARDONI, SANDRA, CHIELLINI, GRAZIA, Carnicelli V, ERBA, PAOLA ANNA, ZUCCHI, RICCARDO, MARIANI, GIULIANO, Manfredi C, Frascarelli S   +7 more
core  

Uptake and metabolic effects of 3-iodothyronamine in rat liver

, 2011
Objectives: 3-iodothyronamine (T1AM) is an endogenous thyroid hormone derivative able to interact with trace amine associated receptors, a family of G protein-coupled receptors, and possibly with other specific molecular targets.
Frascarelli F, GHELARDONI, SANDRA, CHIELLINI, GRAZIA, Saba S, Marchini M, ZUCCHI, RICCARDO   +5 more
core  

Editorial: Thyroid Hormone and Metabolites: Central Versus Peripheral Effects

Frontiers in Endocrinology, 2019
Grazia Chiellini, Federica Cioffi, Rosalba Senese, Pieter de Lange   +3 more
doaj   +1 more source

Commentary: Torpor: The Rise and Fall of 3-Monoiodothyronamine from Brain to Gut—From Gut to Brain?

Frontiers in Endocrinology, 2017
Annunziatina Laurino, Laura Raimondi
doaj   +1 more source

Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway. [PDF]

Int J Mol Sci, 2019
Rogowski M, Bellusci L, Sabatini M, Rapposelli S, Rahman SM, Chiellini G, Assadi-Porter FM.   +6 more
europepmc   +1 more source

3-iodothyronamine (T1AM) induces changes on glutamatergic postsynaptic signaling pathway

, 2019
Objective: Exogenous 3-iodothyronamine (T1AM), a derivative of thyroid hormone, produces antiamnestic and prolearning effects in mice. Glutamatergic neurotransmission, the major excitatory system in brain, plays a key role in regulating neuroplasticity ...
Bandini Lavinia, Ghelardoni Sandra, Zucchi Riccardo, Figuccia Matteo Emanuele, Verlotta Sara, Sacripanti Ginevra   +5 more
core  

3-Iodothyronamine rescues beta-amyloid dependent long term potentiation impairment in the enthorinal cortex

, 2014
Objectives: Beta-amyloid (Abeta) is the principal component of senile plaques, which represent a prominent feature of Alzheimer s disease (AD). However, loss of neuronal function and cognitive impairment precedes Abeta plaque formation.
Sabatini M, SABA, ALESSANDRO, Donzelli R, Criscuolo C, Origlia N., ZUCCHI, RICCARDO   +5 more
core