Results 111 to 120 of about 18,306,088 (139)

The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure. [PDF]

Acta Pharmacol Sin
Liu KY, Gong K, Fang F, Chen QH, Xu JR, Zhang LQ, Chen WL.   +6 more
europepmc   +1 more source

Vasoconstrictor Effects of Trace Amine-Associated Receptor Agonists in the Isolated Perfused Rat Kidney. [PDF]

Med Princ Pract
Jragh D, Yousif MHM, Oriowo MA.
europepmc   +1 more source

Association Analysis Between Ischemic Stroke Risk Single Nucleotide Polymorphisms and Alzheimer's Disease. [PDF]

Bioengineering (Basel)
Dong W, Wang W, Li M.
europepmc   +1 more source

Circulating thyroid hormones and metabolites in children with autism spectrum disorder. [PDF]

Front Endocrinol (Lausanne)
Hancock M, Zhang R, Brown SJ, Boyder C, Mullin S, Campbell PJ, Wilson SG, Lim EM, Whitehouse AJO, Walsh JP.   +9 more
europepmc   +1 more source

Recovery of 3-Iodothyronamine and Derivatives in Biological Matrixes: Problems and Pitfalls

Thyroid, 2017
Background: Difficulties have been reported in quantitating 3-iodothyronamine (T1AM) in blood or serum, and tentatively attributed to problems in extraction or other pre-analytical steps. For this reason, even cell culture experiments have often be performed with unphysiological protein-free media.
Grazia Chiellini, Riccardo Zucchi, Alessandro Saba   +2 more
exaly   +5 more sources

Exogenous 3-Iodothyronamine Rescues the Entorhinal Cortex from β-Amyloid Toxicity [PDF]

Thyroid, 2020
Background: A novel form of thyroid hormone (TH) signaling is represented by 3-iodothyronamine (T 1 AM), an endogenous TH derivative that interacts with specific molecular targets, including trace amine-associated receptor 1 (TAAR
Grazia Rutigliano, Marco Borsò, Riccardo Zucchi   +2 more
exaly   +5 more sources

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Sustained torpidity following multi‐dose administration of 3‐iodothyronamine in mice

Journal of Cellular Physiology, 2011
AbstractDespite significant medical benefits as in space exploration or emergency care, prolonged torpidity of non‐hibernator mammals remains unexplored to date. Here, we report that male Institute of Cancer Research mice could sustain two separate 2‐day torpor bouts and maintain body temperature of 28–33°C following repeated treatments of 3 ...
Hyunwoo, Ju, Hyekyoung, So, Kyungbong, Ha, Kyoungsook, Park, Ju-Woon, Lee, Chan-Moon, Chung, Inho, Choi   +6 more
openaire   +2 more sources

The central effect of 3-iodothyronamine on brain neuropeptides in mice

Comparative Clinical Pathology, 2017
3-Iodothyronamine (T1AM) is an endogenous metabolite of thyroid hormone with noticeable metabolic and neurological effects. Alteration of feeding behaviour by this compound was different at various doses in experimental models and it is not clear whether this effect is partially accounted by changes in neuropeptide secretion.
N. Kazemipour, N. Eskandarzade, R. Beigi, S. Nazifi   +3 more
openaire   +1 more source

3-Iodothyronamine reduces insulin secretion in vitro via a mitochondrial mechanism

Molecular and Cellular Endocrinology, 2018
3-iodothyronamine (3-T1AM), a decarboxylated and deiodinated thyroid hormone metabolite, leads at pharmacological doses to hypoinsulinemia, hyperglucagonemia and hyperglycemia in vivo. As the pancreatic Langerhans islets express thyroid hormone transmembrane transporters (THTT), we tested the hypothesis that not only plasma membrane-mediated 3-T1AM ...
Ina Lehmphul, Carolin S. Hoefig, Josef Köhrle   +2 more
openaire   +2 more sources

3-Iodothyronamine (T1AM): a new chapter of thyroid hormone endocrinology?

Molecular BioSystems, 2010
Abstract 3-Iodothyronamine (T1AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T1AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism.
Alexandra G, Ianculescu, Thomas S, Scanlan   +1 more
openaire   +2 more sources