Results 81 to 90 of about 18,306,088 (139)

Proof of Concept of the Electrochemical Sensing of 3-Iodothyronamine ( T1AM) and Thyronamine ( T0AM) [PDF]

, 2014
Recent studies have shown that, besides the well-recognized T3 and T4 hormones, there are other relevant thyroid hormones circulating in the human body. In particular, this is the case for 3-iodothyronamine (T1AM) and thyronamine (T0AM).
Sousa, JC, Moreira, MM, Inês M. Valente, Compton, Richard G., Scanlan, Thomas S., Thomas S. Scanlan, Scanlan, TS, Rodrigues, JA, Valente, IM, Compton, RG, Valente, Inês M., Sousa, João C., Moreira, Manuela M., Gonçalves, Luís M., Compton, Richard, João C. Sousa, Goncalves, LM, Azevedo, Carla F., José A. Rodrigues, Richard G. Compton, Rodrigues, José A., Manuela M. Moreira, Sousa, João Carlos, Carla F. Azevedo, Azevedo, CF, Luís M. Gonçalves   +25 more
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Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration

Breast Cancer: Targets and Therapy, 2019
Eileen Tremmel,1 Simone Hofmann,1 Christina Kuhn,1 Helene Heidegger,1 Sabine Heublein,2 Kerstin Hermelink,1 Rachel Wuerstlein,1 Nadia Harbeck,1 Doris Mayr,3 Sven Mahner,1 Nina Ditsch,1 Udo Jeschke,1 Aurelia Vattai1 1Breast Center, Department of ...
Tremmel E, Hofmann S, Kuhn C, Heidegger H, Heublein S, Hermelink K, Wuerstlein R, Harbeck N, Mayr D, Mahner S, Ditsch N, Jeschke U, Vattai A   +12 more
doaj  

Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer

Scientific Reports, 2017
Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives may antagonize ...
Elena Shinderman-Maman, Keren Cohen, Dotan Moskovich, Aleck Hercbergs, Haim Werner, Paul J. Davis, Martin Ellis, Osnat Ashur-Fabian   +7 more
doaj   +1 more source

The Case for TAAR1 as a Modulator of Central Nervous System Function

Frontiers in Pharmacology, 2018
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction.
Grazia Rutigliano, Grazia Rutigliano, Alice Accorroni, Alice Accorroni, Riccardo Zucchi   +4 more
doaj   +1 more source

Similarities and Differences in the Peripheral Actions of Thyroid Hormones and Their Metabolites

Frontiers in Endocrinology, 2018
Thyroxine (T4) and 3,5,3'-triiodothyronine (T3) are secreted by the thyroid gland, while T3 is also generated from the peripheral metabolism of T4 by iodothyronine deiodinases types I and II.
Ruy A. Louzada, Denise P. Carvalho
doaj   +1 more source

Synthesis of Rigid Analogs of 3-Iodothyronamine

, 2011
3-Iodothyronamine (T1AM) is a bioactive metabolite of the thyroid hormones, thyroxine (T4) and 3,5,3\u27-triiodothyroxine (T3). T1AM is a potent activator of the Trace Amine Associated Receptor (TAAR1) in vitro.
MacDonald, Alex
core  

N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice [PDF]

, 2019
Introduction: Injection of 3-iodothyronamine into experimental animals profoundly affects their metabolism and body temperature. As 3-iodothyronamine is rapidly acetylated in vivo after injection, it was hypothesized that the metabolites N- or O-acetyl-3-
Sun, Qian, Hoefig, Carolin S., Mittag, Jens, Schomburg, Lutz, Oelkrug, Rebecca, Scanlan, Thomas S., Biebermann, Heike, Gachkar, Sogol, Herrmann, Beate   +8 more
core   +1 more source

Effect of Combined Levothyroxine (L-T₄) and 3-Iodothyronamine (T₁AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse Model of Hypothyroidism. [PDF]

Int J Mol Sci, 2023
Rutigliano G, Bertolini A, Grittani N, Frascarelli S, Carnicelli V, Ippolito C, Moscato S, Mattii L, Kusmic C, Saba A, Origlia N, Zucchi R.   +11 more
europepmc   +1 more source

Low dose 3-iodothyronamine increases acute lipolysis followed by protein catabolism in mouse

, 2012
3-iodothyronamine (T1AM) is a recently discovered fast-acting thyroid hormone derivative. To date, the physiological effects of endogenousT1AM remain elusive, although there is increasing interest in its physiological function and pharmaceutical ...
Haviland, GHELARDONI, SANDRA, CHIELLINI, GRAZIA, Scanlan T, Tonelli M, Butz D, Assadi Porter F, ZUCCHI, RICCARDO, Reiland H   +8 more
core  

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway. [PDF]

Ann Transl Med, 2022
Zhou H, Mo L, Huang N, Zou C, Li C, Lin M, Zhang B, Wei B, Li P, Si X, Chen J, Li W, Liu X, Hu B.   +13 more
europepmc   +1 more source