Results 31 to 40 of about 18,306,088 (139)
The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor [PDF]
Frontiers in Pharmacology, 2018 Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig +10 more
doaj +2 more sources
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection [PDF]
Frontiers in Pharmacology, 2017 3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain.
Lorenza Bellusci +13 more
doaj +2 more sources
LTI Models for 3-Iodothyronamine Time Dynamics: A Multiscale View
IEEE Transactions on Biomedical Engineering, 2011 3-Iodothyronamine (T(1)AM) is a novel relative of thyroid hormone that plays a role in critical body regulatory processes such as glucose metabolism, thermal regulation, and heart beating. This paper was aimed at characterizing time dynamics of T(1)AM and its catabolite 3-iodothyroacetic acid (TA(1)) in different biological scales with linear time ...
Orsi G +3 more
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Characterization of 3-Iodothyronamine In Vitro Dynamics by Mathematical Modeling
Cell Biochemistry and Biophysics, 2013 3-Iodothyronamine (T1AM) is regarded as a hormone-like substance thanks to its endogenous nature, its interaction with specific receptors trace amine-associated receptor 1 and its biological effects. We characterized T1AM transport and conversion in an in vitro culture of H9c2 murine cells, after a T1AM bolus injection.
Orsi G +4 more
openaire +3 more sources
Investigating the biosynthetic and metabolic pathways of 3-Iodothyronamine
, 2015 3-Iodothyronamine (T1AM), an endogenous thyroid hormone derivative, exhibits pharmacological effects opposite to thyroid hormone, including hypothermia, reduced cardiac function, and altered fuel utilization. Structural and metabolic similarities suggest
Hackenmueller, Sarah
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Cardiac metabolism of 3-iodothyronamine
, 2009 Objectives: 3-iodothyronamine (T1AM) is an endogenous relative of thyroid hormone which interacts with plasma membrane receptors known as trace amine-associated receptors, and produces functional effects like hypothermia and reduced cardiac contractility.
CHIELLINI, GRAZIA +6 more
openaire +2 more sources
3-Iodothyronamine, a New Chapter in Thyroid Story
, 2016 Trace amines (TAs) are primary amines structurally related to classic monoamines derived from aminoacid metabolism. Their fast rate of degradation and/or inability to accumulate in substantial concentrations in synaptic vesicles determines their presence
A. Laurino, L. Raimondi
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Cardiac Uptake and Metabolism of 3-Iodothyronamine
, 2010 Abstract: 3-Iodothyronamine (T1AM) is a naturally occurring derivative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors, and to produce significant functional effects, which include reducing body temperature, heart rate and cardiac contractility.
CHIELLINI, GRAZIA +8 more
openaire +2 more sources
Metabolic effects of 3-iodothyronamine in hepatocytes
, 2012 3-iodothyronamine (T1AM) is an endogenous thyroid hormone derivative which produces profound metabolic effects such as a shift in fuel substrate utilization from carbohydrates to lipid. Thus, in the present work we investigated the effects of T1AM on hepatic glucose metabolism.
GHELARDONI, SANDRA +3 more
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3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone
Nature Medicine, 2004 Thyroxine (T(4)) is the predominant form of thyroid hormone (TH). Hyperthyroidism, a condition associated with excess TH, is characterized by increases in metabolic rate, core body temperature and cardiac performance. In target tissues, T(4) is enzymatically deiodinated to 3,5,3'-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH ...
Thomas S, Scanlan +13 more
openaire +3 more sources