Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. [PDF]
Mol Biosyst, 2010 Abstract Thyroid hormone transporters are responsible for the cellular uptake of thyroid hormones, which is a prerequisite for their subsequent metabolism and action at nuclear thyroid hormone receptors. A recently discovered thyroid hormone derivative, 3-iodothyronamine (T1AM), has distinct biological effects that are opposite those ...
Ianculescu AG +4 more
europepmc +5 more sources
Tissue Distribution and Cardiac Metabolism of 3-Iodothyronamine [PDF]
Endocrinology, 2010 3-Iodothyronamine (T1AM) is a novel relative of thyroid hormone, able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors. Significant functional effects are produced by exogenous T1AM, including a negative inotropic and chronotropic effect in cardiac preparations.
Saba A. +10 more
openaire +6 more sources
Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1). [PDF]
Int J Mol Sci, 2022 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1) are thyroid-hormone-related compounds endowed with pharmacological activity through mechanisms that remain elusive. Some evidence suggests that they may have redox features. We assessed the chemical activity of T1AM and TA1 at pro-oxidant conditions.
Gencarelli M +4 more
europepmc +9 more sources
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors [PDF]
European Journal of Pharmacology, 2016 3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic transmission.
LAURINO, ANNUNZIATINA +3 more
openaire +6 more sources
Uptake and metabolic effects of 3-iodothyronamine in hepatocytes [PDF]
Journal of Endocrinology, 2014 3-Iodothyronamine (T 1 AM) is an endogenous relative of thyroid hormone with profound metabolic effects. In different experimental models, T 1 AM increased blood glucose, and it is not clear whether this effect is entirely accounted by changes in ...
Ghelardoni, Sandra +4 more
openaire +4 more sources
3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells [PDF]
Journal of Molecular Endocrinology, 2011 3-Iodothyronamine (T 1 AM), produced from thyroid hormones (TH) through decarboxylation and deiodination, is a potent agonist of trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor belonging to the family of TAARs. In vivo T
Agretti P +12 more
core +7 more sources
Metabolomics of cerebrospinal fluid reveals prognostic biomarkers in pediatric status epilepticus. [PDF]
CNS Neurosci Ther, 2023 Status epilepticus (SE) could induce metabolic changes in brain and could be reflected in cerebrospinal fluid (CSF). Metabolomic analysis using ultra‐performance liquid chromatography quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐QTOF‐MS) was applied to screen potential prognostic biomarkers in CSF of children with SE, by comparing the poor ...
Wang T +13 more
europepmc +2 more sources
Detection of 3-Iodothyronamine in Human Patients: A Preliminary Study [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2012 Context and Objective: The primary purpose of this study was to detect and quantify 3-iodothyronamine (T1AM), an endogenous biogenic amine related to thyroid hormone, in human blood. Design: T1AM, total T3, and total T4 were assayed in serum by a ...
Galli G +8 more
openaire +3 more sources
Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine [PDF]
Frontiers in Pharmacology, 2018 The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized.
Xiaoqun Zhang +11 more
doaj +2 more sources
Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes [PDF]
Frontiers in Endocrinology, 2018 This study was undertaken to determine if crosstalk among the transient receptor potential (TRP) melastatin 8 (TRPM8), TRP vanilloid 1 (TRPV1), and vascular endothelial growth factor (VEGF) receptor triad modulates VEGF-induced Ca2+ signaling in human ...
Ersal Türker +16 more
doaj +2 more sources