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Anticonvulsant and Neuroprotective Effects of the Thyroid Hormone Metabolite 3-Iodothyroacetic Acid [PDF]
Thyroid, 2018 3-Iodothyroacetic acid (TA1) is among the thyroid hormone (T3) metabolites that can acutely modify behavior in mice. This study aimed to investigate whether TA1 is also able to reduce neuron hyper-excitability and protect from excitotoxic damage.CD1 male mice were treated intraperitoneally with saline solution or TA1 (4, 7, 11, or 33 μg/kg) before ...
Annunziatina Laurino, Alessio Masi
exaly +7 more sources
3-Iodothyroacetic acid lacks thermoregulatory and cardiovascular effects in vivo [PDF]
British Journal of Pharmacology, 2015 Background and Purpose3‐Iodothyronamine (3‐T1AM) is an endogenous thyroid hormone derivative reported to induce strong hypothermia and bradycardia within minutes upon injection in rodents. Although 3‐T1AM is rapidly converted to several other metabolites in vivo, these strong pharmacological responses were solely attributed to 3‐T1AM, leaving potential
Jens Mittag +2 more
exaly +5 more sources
3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice [PDF]
British Journal of Pharmacology, 2015 Background and purposeItch is associated with increased sensitization to nociceptive stimuli. We investigated whether 3‐iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli.Experimental ApproachItch was evaluated after s.c. administration of TA1 (0.4, 1.32 and 4 μg·kg−1).
Annunziatina Laurino +2 more
exaly +7 more sources
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3-Iodothyroacetic acid release in a mouse model of ischemia-induced synaptic dysfunction
Endocrine Abstracts, 2022Grazia Rutigliano +2 more
exaly +2 more sources
European Journal of Pharmacology, 2015
3-iodothyronamine (T1AM) and its oxidative product, 3-iodotyhyroacetic acid (TTA1A), are known to stimulate learning and induce hyperalgesia in mice. We investigated whether i)TA1 may be generated in vivo from T1AM, ii) T1AM shares with TA1 the ability to activate the histaminergic system.
Grazia Chiellini +2 more
exaly +5 more sources
3-iodothyronamine (T1AM) and its oxidative product, 3-iodotyhyroacetic acid (TTA1A), are known to stimulate learning and induce hyperalgesia in mice. We investigated whether i)TA1 may be generated in vivo from T1AM, ii) T1AM shares with TA1 the ability to activate the histaminergic system.
Grazia Chiellini +2 more
exaly +5 more sources
Elucidating the actions of 3-Iodothyroacetic acid in thermoregulation and cardiovascular function
Experimental and Clinical Endocrinology and Diabetes, 2014Jens Mittag
exaly +2 more sources
Iodothyronamines are Oxidatively Deaminated to Iodothyroacetic Acids in vivo [PDF]
ChemBioChem, 2009 Aaron Nilsen, Thomas S Scanlan
exaly +2 more sources
2014
Background and purpose 3-iodothyroacetic acid (TA1) is among the end products of thyroid hormone metabolism. To now, it is unknown if TA1 is present in the brain of rodents and if it has any pharmacological effects. Exeprimental approach We measured TA1 levels in the brain of mice by HPLC coupled to mass spectrometry and then we investigated whether ...
Musilli C +10 more
openaire +1 more source
Background and purpose 3-iodothyroacetic acid (TA1) is among the end products of thyroid hormone metabolism. To now, it is unknown if TA1 is present in the brain of rodents and if it has any pharmacological effects. Exeprimental approach We measured TA1 levels in the brain of mice by HPLC coupled to mass spectrometry and then we investigated whether ...
Musilli C +10 more
openaire +1 more source
TRI-IODOTHYROACETIC ACID ABUSE IN A FEMALE BODY BUILDER
Lancet, The, 1986R E Ferner, R E Ferner, M D Rawlins
exaly