Liraglutide Improves Cognitive and Neuronal Function in 3-NP Rat Model of Huntington's Disease. [PDF]
Front Pharmacol, 2021 Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by progressive motor, psychiatric, and cognitive abnormalities. The antidiabetic drug liraglutide possesses a neuroprotective potential against several neurodegenerative disorders; however, its role in Huntington’s disease (HD) and the possible ...
Shawki SM +4 more
europepmc +6 more sources
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3'-NP-DNA up to 25 Nucleotides Long Inside Model Protocells. [PDF]
J Am Chem Soc, 2019 Efficiently copying mixed-sequence oligonucleotide templates nonenzymatically is a long-standing problem both with respect to the origin of life, and with regard to bottom up efforts to synthesize artificial living systems. Here we report an efficient and sequence-general nonenzymatic process in which RNA templates direct the synthesis of a ...
O'Flaherty DK, Zhou L, Szostak JW.
europepmc +5 more sources
Peroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin. [PDF]
Iran J Pharm Res, 2019 Peroxisomes are single membrane cell organelles with a diversity of metabolic functions. Here we studied the peroxisomal dysfunction and oxidative stress after 3-nitropropionic acid (3-NP) induced neurotoxicity and the possible protective effects of oxytocin. Adult male and female rats were subjected to OXT and/or 3-NP treatment.
Moslemi M +3 more
europepmc +4 more sources
PDGFR-β-Positive Perivascular Adventitial Cells Expressing Nestin Contribute to Fibrotic Scar Formation in the Striatum of 3-NP Intoxicated Rats. [PDF]
Front Mol Neurosci, 2018 Perivascular cells expressing platelet-derived growth factor receptor beta (PDGFR-β) have recently been implicated in fibrotic scar formation after acute brain injury, but their precise identity and detailed morphological characteristics remain elusive.
Riew TR, Choi JH, Kim HL, Jin X, Lee MY.
europepmc +5 more sources
Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2. [PDF]
Cell Mol Neurobiol, 2022 Huntington disease (HD) is a progressive neurological disorder with dominant motor symptoms. It also has psychiatric manifestations, like anxiety and depression, that can emerge themselves before motor symptoms and impose a major burden on patients. Oxytocin (OXT) is a newly emerged treatment for disorders like autism and schizophrenia and recently is ...
Khodagholi F +5 more
europepmc +4 more sources
Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease [PDF]
Frontiers in Molecular NeuroscienceImpaired mitochondrial function has been associated with the onset of neurodegenerative diseases. Specifically, certain mitochondrial toxins, such as 3-nitropropionic acid (3-NP), initiate cellular changes within the striatum that closely resemble the ...
Elizabeth Hernández-Echeagaray +3 more
doaj +4 more sources
Neuroprotective effect of Zingiber officinale in 3-np-induced huntington disease
IOSR Journal of Pharmacy (IOSRPHR), 2012 –Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disease that causes clinical manifestations such as progressive choreiformic movements, cognitive abnormality and psychiatric deterioration. HD results from the destruction of neurons in the basal ganglia, and oxidative stress, Exitotoxicity and energy impairment hasbeen ...
Manisha Sharma
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Experimental Gerontology, 2017 Cardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP).
A, Silva-Palacios +9 more
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Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway [PDF]
Cell Death & Differentiation, 2009 Mitochondrial respiratory complex II inhibition plays a central role in Huntington's disease (HD). Remarkably, 3-NP, a complex II inhibitor, recapitulates HD-like symptoms. Furthermore, decreases in mitochondrial fusion or increases in mitochondrial fission have been implicated in neurodegenerative diseases.
G, Liot +5 more
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Prosthesis retention after an infected hip prosthesis: hip fractures versus primary total hip prosthesis, data from 1998 - 2015 [PDF]
Journal of Bone and Joint Infection, 2018 Background: A prosthetic joint infection (PJI) is a serious complication and specifically a burden for patients after hip fracture surgery, as they are mostly frail elderly patients with multiple comorbidities. Since treatment protocols are lacking there
L. M.A. de, W. C. Neve, J. Steens
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